Analgesic Activity Of Artesunate By Central Mechanism In Experimental Animal - Model
Journal Title: International Journal of Medical and Health Sciences - Year 2012, Vol 1, Issue 3
Abstract
The present study was undertaken to assess the central analgesic effect of Artesunate in Swiss albino mice. The analgesic action in acute pain model was studied by the tail flick method. Thirty six swiss albino mice were divided into three groups of twelve animals (six males and six females) each and maintained under ideal laboratory conditions. Group I was taken as control and group II treated with Pentazocine (50mg/kg intraperitonially) and group III was treated with Artesunate (36.4mg/kg intraperitonially). In the present study, the effect of artesunate alone for its central analgesic activity has been evaluated. It was observed that Artesunate possess a significant (p<0.001) central analgesic activity. The central analgesic activity of Artesunate can be due to rise in the pain threshold and thus increase the capacity to tolerate pain as its activity has been compared with pentazocine.
Authors and Affiliations
Shyamjith Mannikoth, Manohar V. R, Chandra shekar. R, Rao S. N
Keywords
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