Biochemical pathways and targeted therapies in basal cell carcinoma: A systematic review
Journal Title: Journal of Surgical Dermatology - Year 2017, Vol 2, Issue 1
Abstract
Basal cell carcinoma (BCC) is the most common type of human malignancy. It is a slow-growing skin cancer with little ability to metastasize, but it is aggressive and can cause local tissue destruction. Descriptions of Basal Cell Nevus Syndrome (BCNS), characterized by a predisposition to the formation of BCC and other neoplasms, and identification of the genetic defect in this syndrome, has led to significant advancement in our understanding of the pathogenesis of BCC. Unregulated expression of target genes in the sonic Hedgehog (SHH) signaling pathway plays a prominent role in the pathogenesis of BCC. An understanding of the signaling components has allowed for the development of pharmacologic agents that inhibit the SHH pathway. The first inhibitor of the SHH pathway approved by the Food and Drug Administration (FDA) for the treatment of BCC is vismodegib. In this review, we will discuss the biochemical pathways involved in BCC as targets of novel pharmacologic therapies.
Authors and Affiliations
Bao Anh Patrick Tran, Tiffany Alexander, Ally-Khan Somani
Keywords
Related Articles
- EP ID EP680056
- DOI -
- Views 224
- Downloads 0
Vascular compromise secondary to fillers injection: Minimizing sequelae
The use of filler injections for facial rejuvenation and sculpturing has become a keystone of esthetic medicine.
Laser microporation: A promising field in transdermal drug delivery
Topical therapy is an expanding field not only in dermatology but also in other fields of medicine. An expanding list of systemic medications have been applied topically in several dermatologic conditions. Drugs applied...
Paramedian forehead flap for nasal tip reconstruction after Mohs surgery
The paramedian forehead flap is a great option for restoring complex nasal defects. Its main indications are large and deep wounds located on the distal third of the nose (tip and ala). For full-thickness defects, the pa...
Treatment of multiple scalp cylindroma
Cylindroma is a rare, benign adnexal tumor of the skin. The most frequent tumor location is the head, especially the scalp, and neck area. This type of tumor can occur as solitary or multiple tumors. Tumor diagnosis is r...
The use of folded melolabial interpolation flaps to repair full thickness distal nasal defects: A review of technique and results
The nose is a common site for skin cancer and there are several surgical options available for reconstruction after excision. Traditional surgical teaching suggests that in the case of a partial full thickness defect inv...