Effect of Intravenous Fentanyl and Magnesium Sulphate in General Anesthesia and Surgery During Peri-Operative Period – A Randomized Comparative Study
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 6
Abstract
Aim and Background: Success of all major and specialized surgical procedures under general anesthesia depends on balanced anaesthetic techniques, with minimal hemodynamic disturbance to the patients. Aim of this study is to compare the hemodynamic effects of intravenous Magnesium sulfate & Fentanyl citrate in surgical procedures, under general anaesthesia during intubation, intra-operative and postoperative period and their significant side effects if any. Methods and Materials: This prospective, randomized study was carried out on 60 ASA grade I or II patients, scheduled for elective surgeries, requiring general anaesthesia with endotracheal intubation. 2 groups of 30 each. F Group - Patients were given Fentanyl citrate. M Group - Patients were given Magnesium sulfate as the study drug. Results: Mean change in pulse rate and mean arterial pressure (MAP) after intubation was more for M Group. Pulse rate and MAP reached near baseline value at 5 minutes after intubation in F group, while in 10 min. after intubatio n in M group. 3 hrs after surgery all the patients in F group were given first dose of analgesic but in M group, only 2 and 10 patients were given first dose of analgesic while 3 and 15 patients were having no pain and mild pain respectively. Conclusion: Magnesium sulfate provides intra-operative hemodynamic stability like fentanyl citrate, though not superior to that provided by Fentanyl citrate. Magnesium sulfate can be considered as a useful and good alternative to Fentanyl citrate, especially in circumstances, where the complications associated with opioids are undesirable.
Authors and Affiliations
Dr K. Rajarajeswaran
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