Genetic pheochromocytoma/paraganglioma– A review
Journal Title: Scientific Journal of Medical Science - Year 2013, Vol 2, Issue 11
Abstract
The prevalence of pheochromcytoma in hypertensive patients is less than 1%.Most PHEOs occur sporadically, but a substantial proportionmay be associated with germ line mutations of genes predisposing to thedevelopment of familial syndromes like multiple endocrineneoplasia(MEN),Von-Hippel Lindau(VHL) disease,neurofibromatosis type 1(NF-1),familial paraganglioma/pheochromocytoma (PGL/PHEO) related to geneticmutation encoding the mitochondrial protein succinate dehdrogenase sub units(SDH-BCD) .Screening for genetic mutation is imperative as it may add more onmanagement and surveillance of this patients .This review summarize therelevant data related to this fascinating clinical entity.
Authors and Affiliations
F. B. Pambinezhuth| National Diabetes and Endocrine center –Royal hospital, Muscat Oman.
Keywords
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- EP ID EP1251
- DOI 10.14196/sjms.v2.i11.1023
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