Improvement of Solubility and Dissolution of Indomethacin by Liquisolid and Compaction Granulation Technique
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2009, Vol 1, Issue 3
Abstract
The purpose of this study was to develop novel techniques to enhance the dissolution rate of poorly watersoluble drugs substance Indomethacin (IM).The granules of IM were prepared by nonaqueous liquisolid andcompaction technique by using different excipients. As per the novel formulation method of liquisolid compacts, liquid medications such as solutions or suspensions of water insoluble drugs in appropriate nonvolatileliquid vehicles, can be converted into suitably flowing and compressible powders by blending with particular powder excipients. In the liquisolid system, IM was dispersed in Polyethylene glycol-400 (PEG 400)as a non volatile liquid vehicle. Microcrystalline cellulose (Avicel PH 102) and dibasic calcium phosphate (DCP) were used as the carrier, Hydroxypropylmethyl cellulose (HPMC) was used as coating material andsodium starch glycolate (SSG) and crosscarmellose sodium (CCS) were used as disintegrants.The granules were also prepared by compaction technique with the same excipients except non volatile liquid vehicle (PEG400).The obtained granules from liquisolid compact system display enhanced solubility and invitro release profiles due to the increased wetting properties and surface of drug available for dissolution compared to granules obtained from compaction technique and physical mixture. It was also observed that the drug release rate, water solubility and wettability of liquisolid granules containing super disintergrants were on higher side compared to liquisolid granules without superdisintegrants.
Authors and Affiliations
Yadav V. B
Keywords
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