Application of Helicobacter pylori antigen test to evaluate gastric mucosa specimens
Journal Title: Progress in Health Sciences - Year 2014, Vol 4, Issue 2
Abstract
Purpose: To investigate, whether the test documenting the presence of Helicobacter pylori (H. pylori) antigens in the gastric mucosa may be used as diagnostic test. Materials and methods: Mucosal specimens taken from eighty-three patients during gastroscopic examination were subjected to rapid urease test (CLO test), histology, and H. pylori culture. The same biopsy specimens that had been evaluated in the CLO test or collected into the transport medium for bacterial culture were used to detect H. pylori antigens. An amplified immunoassay for the detection of H. pylori antigens in stool was used for gastric mucosa specimens. The sensitivity and specificity of the H. pylori antigen test were evaluated in relation to the results of each verifying test (CLO test, histology, culture) separately and to all 3 tests analysed together. Results: The sensitivity and specificity of the H. pylori antigen test in relation to the CLO test, histological examination, and H. pylori culture were 85.4% and 90.5%, 76.1% and 83.4%, and 90.7% and 90.0% for specimens taken for the CLO test and 90.0% and 82.0%, 78.0% and 81.0%, and 93.0% and 88.0% for specimens taken for bacterial culture, respectively. The sensitivity and specificity of the antigen test in relation to all 3 verifying tests analysed together were 91.3% and 97.3% for specimens taken for the CLO test, and 91.7% and 97.1% for specimens taken for bacterial culture, respectively. Conclusions: H. pylori antigen test in gastric mucosa specimens may be a sufficiently reliable source of information about stomach infection.
Authors and Affiliations
A. Namiot, K. Leszczyńska, DB Namiot, M. Chilewicz, Bucki, Z. Namiot
Keywords
Related Articles
- EP ID EP132156
- DOI -
- Views 101
- Downloads 0
Sinusogenes orbital complication as the first symptom of refractory granulomatosis with polyangiitis and the use of rituximab in treatment. A case report
Granulomatosis with polyangiitis (GPA) is a rare disease involving multiple organs and systems, characterized by necrotizing inflammation of small and medium-sized vessels and formation of granulomas. There are several f...
Albert Schweitzer – the centenary of the hospital in Lambarene, Gabon
The authors discuss the activities and achievements of Albert Schweitzer in their principal fields—music and musicology, philosophy and theology, and medicine and hospital management. They also describe Schweitzer’s succ...
A study on knowledge, attitude and practices about organ donation among college students in Chennai, Tamil Nadu -2012
Introduction: Assessment of knowledge, attitude and practices on organ donation is essential for better understanding of the community on different aspects of organ donation. It will further help us in improving health e...
Lower limb oedema in vascular disease
Introduction: Lower limb oedema is a significant problem in vascular diseases. Due to the localization, it greatly hampers normal mobility affecting quality of life. Purpose: To evaluate the frequency of lower limb swel...
Assessment of psychological distress and quality of life in lung cancer patients receiving chemotherapy: A single center experience
Background: Lung cancer is one of the most common malignant diseases with high mortality. Patients diagnosed with lung cancer are most likely to exhibited psychiatric symptomatology while they experience poor quality of...