Possible effect of tea plant parasite, Scurrula atropurpurea (Blume) Danser, on growth inhibition of culture HeLa cells in vitro through DNA repair and apoptosis intrinsic pathways mechanism
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2015, Vol 5, Issue 9
Abstract
Objective: To study the possible in vitro effect of tea plant parasite [Scurrula atropurpurea (Blume) Danser] extract on HeLa cells culture growth inhibition through DNA repair and apoptosis intrinsic pathways mechanism. Methods: Flow cytometry assay were performed for those analyses. Results: For DNA repair pathway mechanism, treatment of tea plant parasite extract decreased MDM2 expression and increased p21 expression. And for apoptosis markers measurement on bax and bcl-2 showed an opposite result, increasing on bax and decreasing on bcl-2 expression. Almost all doses treatment in all measurement showed significantly result. Conclusions: This result showed an effect of tea plant parasite extract on inhibition of cells HeLa culture growth through DNA repair and apoptosis intrinsic pathways mechanism.
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- DOI 10.1016/S2222-1808(15)60924-0
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