The Effects of Glutamine and N-Acetylcysteine on Experimental Colitis Induced by 2,4,6-Trinitrobenzene Sulphonic Acid in Rats
Journal Title: Türk Kolon ve Rektum Hastalıkları Dergisi - Year 2019, Vol 29, Issue 2
Abstract
Aim: Various factors including free oxygen radicals were have been described in the pathogenesis of inflammatory bowel disease. The aim of this study was to investigate the effects of antioxidant N-acetylcysteine (NAC) and combined glutamine (Gln) on experimental colitis. Method: In order to achieve this, rats were randomized and administered intraperitoneal NAC or oral Gln + intraperitoneal NAC one day after experimental colitis model induced with trinitrobenzen sulphonic acid. After the treatment, the rats were sacrificed and colon damage was evaluated macroscopically and microscopically. Malonyldialdehyde level and superoxide dismutase activity were analyzed biochemically. Results: NAC and Gln + NAC groups showed macroscopically better results than the colitis group. Histopathologically, all treated groups provided significantly lower scores than the colitis group. Similarly, all treated groups provided better biochemical results than the colitis group. Conclusion: According to the results of the experiment, it was concluded that NAC had positive effects on experimental colitis model.
Authors and Affiliations
İsmail Cem Eray, Orçun Yalav, Kubilay Dalcı, Ahmet Rencüzoğulları, Ahmet Gökhan Sarıtaş, Ömer Alabaz, Şule Menziletoğlu Yıldız, Gülşah Seydaoğlu, Figen Doran
Keywords
Related Articles
- EP ID EP582124
- DOI 10.4274/tjcd.galenos.2019.47640
- Views 101
- Downloads 0
Should Web-Based Education Be Implemented for Colorectal Cancer Patients?
Improved access to health-related information through increased access to the internet can be viewed as an important opportunity for both healthcare professionals and patients. The internet has fundamentally changed the...
Anterior Sphincteroplasty Procedure Should Be Considered in the Treatment of the Rectocele Because of the Incomplete External Anal Sphincteric Rupture Accompaniment
.
Evaluation of Etiological Risk Factors in the Development of Adult Chronic Pilonidal Disease
Aim: Pilonidal disease has a high rate of recurrence after surgical interventions and measures that can be taken to prevent the recurrence are gaining importance. This study was planned to review the possible risk factor...
Evaluation of Postoperative Headache, Back Pain and Urinary Retention in Benign Anorectal Surgical Patients Under Spinal Anesthesia
Aim: Benign anorectal diseases are common surgical procedures in general surgery. Various anesthetic techniques are utilized during surgical procedures. In this study, postoperative headache, urinary retention, and back...
Risk Factors in Anastomotic Leaks After Low Anterior Resection for Rectal Cancer and the Effects of Diverting Stoma on Clinical Results
Aim: The aim of this study was to determine the risk factors which might render patients who underwent rectal cancer surgery prone to anastomotic leaks (AL) and to investigate whether diverting stoma (DS) alleviated the...