1,3-Dibromo-5,5-dimethylhydantoin: a versatile catalyst for synthesis of 3,3-bis(indolyl)oxindoles
Journal Title: Iranian Chemical Communication - Year 2013, Vol 1, Issue 1
Abstract
A condensation of various isatins with indole derivatives has been carried out in the presence of 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) as catalyst at 50 °C in ethanol in order to form 3,3-bis(indolyl) oxindoles. The products were obtained within 20-90 min by 70-96% yields. The efficacy of the procedure has been confirmed by catalyzing the condensation reaction of pyrrole which was used as another sort of heterocycle with indole to obtain its corresponding 3,3-bis(2-pyrrolyl)oxinole. A plausible mechanism of the condensation based on DBDMH activating role has also been proposed. DBDMH is an effective, commercially available, insensitive to moisture and easily handling catalyst. Simple procedure, easy work-up, mild reaction conditions, high yields and short reaction times are the highlighted points of reported method.
Authors and Affiliations
Seyyedeh Fatemeh Hojati, Dr. Kobra Nikoofar, Zahra Etemadifar
Keywords
Related Articles
- EP ID EP252829
- DOI -
- Views 150
- Downloads 0
One-pot multicomponent reaction for the synthesis of 2-amino-4-chromenes promoted by 1-methyl imidazoliumiodide [mim]Cl ionic- liquid catalyst under solvent-free conditions
simple, clean, and environmentally benign three-component process for the synthesis of 2-amino-4Hchromenes using [mim]Cl, as an efficient catalyst under solvent-free conditions are described. A wide range of aromatic ald...
Determination of the absolute redox potential of methyldopa: experimental and simulation methodes
The conditional formal potential, E°′of Methyldopa has been studied by cyclic voltammetry at the surface of activated glassy carbon electrode (AGCE) as the working electrode in different pH phosphate buffered solutions....
http://sci-hub.tw/10.1007/s13738-018-1312-4
Stachys is one of the largest genera in the flowering plant family. It is in the subfamily Lamioideae (Labiatae), spreading and growing in different parts of Iran. The purpose of this study was to investigate the chemica...
The effect of time and temperature on the growth and morphology of cupper oxide nanostructures
Cupper Oxide structures with a variety of novel morphologies are synthesized using cupper foil as substrate via a solution route. The structure, morphology and phase of the as-synthesized nanostructures are analyzed by v...
The preparation of quinoxaline and 2,3-dihydropyrazine derivatives using Selectfluor as an efficient and reusable catalyst
Selectfluor [1-(chloro methyl) -4-flouro -1,4-di azonia bicyclo[2,2,2] octane bis (tetraflouro-borate)] catalyzed the preparation of quinoxaline and 2,3-dihydo pyrazine derivatives through one -pot condensation of 1,2-di...