2-Arachidonoylglycerol (2-AG) membrane transport: History and outlook
Journal Title: The AAPS Journal - Year 2006, Vol 8, Issue 2
Abstract
Only a few studies have addressed the transport of 2-arachidonoylglycerol (2-AG), a naturally occurring agonist for cannabinoid receptors. Based upon saturation kinetics, these early reports have proposed that 2-AG enters the cell by a specific 2-AG transporter, via the putative anandamide transporter, or by simple diffusion. In this review, the uptake of 2-AG is discussed in light of the recent advances that have been made for anandamide transport, where the mechanism appears to be rate-limited diffusion through the membrane. Endocannabinoids may be a distinct class of agonists since they are hydrophobic and neutral, exhibiting similar biophysical properties to some anesthetics that freely diffuse through the membrane.
Authors and Affiliations
Anita Hermann, Martin Kaczocha, Dale G. Deutsch
Keywords
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