28-Homocastasterone: A Novel Plant Ketosteroid Enhances Tissue Transaminase Catalytic Activity and Gene Expression in Normal and Diabetic Male albino wistar Rat
Journal Title: International Journal of Clinical Pharmacology & Toxicology(IJCPT) - Year 2016, Vol 5, Issue 5
Abstract
28-Homocastasterone (28-HC) is a brassinosteroid family phytohormone. Humans were exposed through diet and herbal based folk medicine, although its mammalian cellular influence unknown. Present study investigated 28-HC cellular metabolic enzyme inductivity on tissues in normal and diabetic rats. Induction of diabetes was achieved by single peritoneal injection of STZ (60mg/kg.bwt) followed by 28-HC were feed orally 15 days, daily. At end of 15th day tissues was removed followed by enzyme activity and mRNA expression of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) was analysed. 28-HC treated rat tissues ALT, AST, GGT and ALP catalytic activity and mRNA expression increased significantly (P<0.05). Dietary plant ketosteroid 28-HC augmented transaminase and phosphatase activity in tissues resulted to cellular transamination and phosphorylation status affected by this plant steroid in rat. It is suggested that 28-HC supplemented diets may be suitable for higher energy related work activities in man and animals.
Authors and Affiliations
Kotteazeth Srikumar
Keywords
Related Articles
- EP ID EP201761
- DOI 10.19070/2167-910X-1600037
- Views 69
- Downloads 0
A Possible Association of Sex Hormone-Binding Globulin with Weight Gain in the Valproic Acid-Treated Female Patients with Epilepsy
Weight gain is a common adverse consequence of treatment with valproic acid. Although a low sex hormone-binding globulin (SHBG) level was shown to be an independent risk factor for the development of metabolic syndrome a...
Anticancer Agents: A Review of Relevant Information on Important Herbal Drugs
Cancer has almost created havoc amongst the human society as the number of mortalities is increasing day-by-day and year after year. Numerous studies have been done to find out the cure for cancer but to no avail. Herbal...
Genomic Biomarkers for Personalized Medicine in Breast Cancer
Genomic Biomarkers for Personalized Medicine in Breast Cancer
PPAR α/γ Agonist in Management of Diabetic Dyslipidemia: A Review
Cardiovascular diseases are major contributors of mortality and morbidity in patients with type 2 diabetes mellitus (T2DM), while dyslipidemia and hyperglycemia are key modifiable risk factors to prevent coronary artery...
Forensic Relevance of The Suicide Tree “Cerebra Odollam”
Cerbera odollam is a powerful toxic plant that is responsible both for suicide and homicide. The seeds are excessively toxic, containing cerberin as the main active cardenolide. Cerberin is difficult to detect in autopsi...