8 Hours Infusional 5-Fluorouracil (5-FU) Concurrent with Neo-Adjuvant Radiotherapy in Locally Advanced Rectal Cancer
Journal Title: Scholars Academic Journal of Biosciences - Year 2015, Vol 3, Issue 5
Abstract
Abstract: In order to selecting optimal treatment regimen in patients suffered advanced rectal cancer, combined adjuvant radiochemotherapy has been found to be more effective than radiotherapy or surgery alone. 5-fluorouracil (5-FU) given concomitantly within the first week of radiotherapy has been shown to be potentially effective, especially before surgical resection of tumor. In the present study, we planned a regimen including preoperative 5-FU infusion within 8 hours concurrently with radiotherapy to assess the efficacy of this protocol without needing hospitalization and with minimizing therapeutic regimen side effects in patients with locally advanced rectal cancer. Sixteen consecutive patients locally advanced rectal cancer (clinical stage T3–T4 or any T stage with positive nodal involvement) received 5FU delivered by continuous infusion within 8 hours, concomitantly with radiotherapy. 5FU dosage was planned at 1000 mg/m2 (ranged 1500 to 1800 mg). Patients were clinically examined and laboratory parameters were assessed every week for six weeks and then were operated. At the 5FU dose of 1000 mg/m2, 8 patients presenting with cytopenia that only 3 of them needed to subcutaneous injection of Neupogen. Gastrointestinal events including diarrhea was revealed in 6 patients that was improved by appropriate nutritional regimen and using Loperamide, but radiotherapy was stopped in other 2 patients. Five patients needed to blood transfusion because of the appearance of serum hemoglobin less than 8.5 g/dl. Two patients were administered to be rest at home for one week. All patients completed their treatment and underwent surgery 6 weeks later. The preoperative radiochemotherapy regimen used in the present study incurs a low rate of complications with an acceptable controlled morbidity. Routine use of preoperative adjuvant chemoradiotherapy including 5-FU 1000 mg/m2 within 8 hours concurrently with radiotherapy can be warranted as standard treatment in locally advanced rectal cancer. Keywords: adjuvant chemoradiotherapy, 5-fluorouracil, rectal cancer
Authors and Affiliations
Mehrsa Majdaeen, Abbas Rahimi, Mohammad Babaei, Masoumeh Karimi, Gholamreza Ataei
Keywords
Related Articles
- EP ID EP379051
- DOI -
- Views 69
- Downloads 0
Response of Anisopteromalus calandrae (Hymenoptera: Pteromalidae) to variation in densities of its host Callosobruchus maculatus (Coleoptera: Chrysomelidae) within stored grains of Vigna subterranea (L.) Verdc (Fabaceae)
Bambara groundnut [Vigna subterranea (L.) Verdc (Fabaceae)] is an important source of protein for rural populations in sub-Saharan Africa. During storage, this commodity is destroyed by Callosobruchus maculatus (Coleopte...
Importance of microbial analysis of Cling film in food packaging industry
Plastic packaging which is a critical control point is very often contaminated with microorganisms during production. This aim of present study is to isolate and characterize dominant species found in food quality Cling...
Clinical Profile & Management of Patients of Carcinoma Anorectum: A Retrospective and Prospective Study
Abstract: In the present study, we have done a retrospective as well as prospective study for the clinical profile of patients with carcinoma anorectum undergoing abdominoperineal resection, with special emphasis on clin...
Aqua cultural attributes of some water physicochemical parameters: A review
Water quality is essential for successful aquaculture development. Anthropogenic activities mostly as a result of industrial and agricultural activities are the major sources of water pollution in an aquatic environment....
Biological evaluation of 2-arylidene-4-(4-phenoxy-phenyl) but-3-en-4-olides
Abstract: A series of 2-Arylidene-4-(4-Phenoxy-Phenyl) But-3-en-4-olides were screened against Pheretima posthuma earthworm for anthelmintic activity. The in vitro effects of compounds were evaluated at a concentration o...