(9) ROLE OF TRANEXAMIC ACID FOR REDUCING BLOOD LOSS IN TETRALOGY OF FALLOT
Journal Title: Indian journal of applied basic medical sciences - Year 2014, Vol 16, Issue 22
Abstract
BACKGROUND: Antifibrinolytic agents are used to reduce post-operative blood loss during cardiac surgeries. Paucity of literature on tranexamic acid in patients undergoing tetralogy of fallot repair encouraged us for this study at a tertiary cardiac care center. Administration of antifibrinolytic agent tranexamic acid decreases bleeding and transfusions during postoperative period. METHODS : Sixty pediatric patients undergoing surgical repair for tetralogy of fallot were divided into two groups. The control (Group-A) did not receive the drug while the study group (Group-B) received IV tranexamic acid at pre-incision, during priming and heparin reversal at 10 mg/kg. Blood loss, need for supplementation of blood and blood products, coagulation parameters and re-exploration rate were compared between the groups. RESULTS : Both groups had comparable demographic parameters (age, weight, and body surface area and tetralogy of fallot characteristics). Tranexamic acid treated patients experienced lesser blood loss (p<0.0003), need for PCV (p<0.0001) or Fresh Frozen Plasma (FFP; p<0.0001). Improved coagulation parameters [increased Fibrinogen content (p<0.01) and platelets (p<0.01); decreased activated clotting time (p<0.01) and fibrin degradation product (p<0.01) were also seen in drug treated patients. CONCLUSION: Tranexamic acid was effective in reducing post-operative blood loss with improved coagulation parameters. We therefore advocate its routine use for tetralogy of fallot repair surgeries in pediatric patients.
Authors and Affiliations
R D Patel, Rajesh Thosani
Keywords
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