A BIOCHEMICAL APPROACH TO LACTATE DEHYDROGENASE IN ASCITIC/PLEURAL FLUID IN A TERTIARY CARE HOSPITAL
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2019, Vol 8, Issue 2
Abstract
BACKGROUND Lactate dehydrogenase (LDH) is an enzyme which is found in almost all living cells. LDH is a tetramer composed of two different subunits, M and H. It catalyses the interconversion of lactate and pyruvate, as it interconverts NAD+ and NADH. The aim of this study was to evaluate the diagnostic significance of estimating lactate dehydrogenase in ascitic and pleural fluid. MATERIALS AND METHODS The current study was conducted in the department of biochemistry at Saraswathi Institute of Medical Sciences, Hapur. This descriptive study was performed on 60 subjects suffering from ascites/pleural effusion, who satisfy the inclusion and exclusion criteria. Since the duration of the study was less, patients were selected by convenience technique. RESULTS Estimating the fluid lactate dehydrogenase levels in patients presenting with ascites helps in differentiating between malignant and non-malignant effusions. It is highly sensitive (100%) and highly specific (100%). Estimating the fluid lactate dehydrogenase level in patients presenting with pleural effusion helps in differentiating between transudative and exudative effusions. It is highly sensitive (100%) and highly specific (100%). CONCLUSION Biochemical analysis of LDH in ascitic fluid helps in differentiating malignant and non-malignant aetiology (Negative Predictive Value= 100%, Confidence Interval= 75.3-100%).
Authors and Affiliations
Vivek Sinha, Poonam Kachhawa
Keywords
Related Articles
- EP ID EP553080
- DOI 10.14260/jemds/2019/31
- Views 100
- Downloads 0
ANAESTHETIC MANAGEMENT IN A PATIENT WITH ARNOLD-CHIARI MALFORMATION TYPE I AND SYRINGOMYELIA
Syringomyelia is an unusual neurological condition characterised by the the presence of cystic cavity in the spinal cord resulting in neurological manifestations. Here, we report a safe anesthetic management of...
PRONE VENTILATION FOR SEVERE ARDS IN A PERIOPERATIVE CAESAREAN PATIENT
PRESENTATION OF CASE A 33-year-old pregnant female at 30 weeks gestation was referred from another hospital with fever, rhinitis, productive cough, progressive dyspnoea and myalgia of 1 week duration. Her past history wa...
COMPARISON OF SOCIODEMOGRAPHIC AND CLINICAL VARIABLES IN SCHIZOPHRENICS WITH AND WITHOUT SUBSTANCE ABUSE
BACKGROUND Substance abuse is associated with poor outcome in schizophrenia patients. Alcohol and cannabis were reported to be most commonly abused substances in schizophrenics. Great care is needed to manage th...
POST CAESAREAN SCAR ENDOMETRIOSIS - A RARE DISEASE ENTITY
Endometriosis is a common gynaecological condition. It can pose a diagnostic dilemma when presented as endometriosis in the scar. This is a rare disease entity. We discuss a case of abdominal wall endometriosis...
KNOWLEDGE AND ATTITUDE REGARDING TUBERCULOSIS TREATMENT AMONG DOT PROVIDERS OF RNTCP REGISTERED PATIENTS IN KOTTAYAM DISTRICT, KERALA
BACKGROUND DOT Provider’s knowledge, attitudes and perceptions about Tuberculosis play an important role in their ability to care for individuals with Tuberculosis and is a major determinant of successful completion of T...