A CLINICAL STUDY OF THE CUTANEOUS MANIFESTATIONS OF LUPUS ERYTHEMATOSUS
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 31
Abstract
BACKGROUND Lupus Erythematosus (LE) is a group of heterogenous autoimmune diseases with an array of manifestations ranging from cutaneous lesions to life-threatening systemic manifestations. Cutaneous manifestations are the second most common feature and it serves as an important diagnostic aid. The nonspecific skin lesions are associated with more active disease. The aim of the study is to study the pattern and prevalence of cutaneous manifestations in LE and to study the correlation between cutaneous manifestations and systemic involvement. MATERIALS AND METHODS Study comprised of 48 patients of lupus erythematosus who attended the Department of Dermatology and Venereology in a tertiary referral centre from a period of November 2010 to November 2012. Patients were subjected to detailed clinical examination, routine investigations, ANA, anti-dsDNA, ANA profile, non-lesional skin biopsy for lupus band test. RESULTS 48 patients were taken for the study. The peak incidence was in the age group of 30-40 (33.33%) yrs. There was female predominance, the ratio being 5.86:1. Discoid Lupus Erythematosus (DLE) constitutes 37.5% and Systemic Lupus Erythematosus (SLE) 62.5%. Majority of DLE patients (38.89%) presented late in 5-9 yrs., whereas SLE patients presented early within 1-6 months (50%). Most frequent presenting features were arthralgia (54.17%), oral ulcers (45.83%). Renal system was the most common system affected (16.67%). Most common haematological abnormality was anaemia and raised ESR (40%). Most common immunological abnormality was raised ANA in 66.7% and raised anti-dsDNA (60%). Most frequent biochemical abnormality was albuminuria and raised 24-hours urine protein. Lupus band was positive in 58.33% and all had renal involvement. Mortality was 6.67%. CONCLUSION In this study, we got comparable results in epidemiological parameters like age and distribution with other studies. The incidence of ANA negative SLE was higher (33.33%) in our study. Though majority of patients with renal involvement had a positive lupus band test, a statistical significance could not be sought in this regard on account of low sample size.
Authors and Affiliations
Celine Machiyanickal Issac, Sobhanakumari Kunjumani, Surabhi Surabhi, Mary Vineetha
Keywords
Related Articles
- EP ID EP217998
- DOI 10.18410/jebmh/2017/361
- Views 108
- Downloads 0
A STUDY ON POSTNATAL OUTCOME OF FOETAL CHOLELITHIASIS
BACKGROUND The first prenatal diagnosis of cholelithiasis was done by Beretsky and Lankin in 1983. Foetal cholelithiasis is a rare finding during a third trimester of pregnancy. Despite the remarkable number of foetal sc...
ANALYSIS OF DONOR CORNEA RETRIEVAL DATA- HOSPITAL AND RESIDENCES
BACKGROUND The voluntary eye donation is still the most popular methods of eye donation in our country. Since last three decades, the voluntary eye donation is promoted by a number of NGOs and Government of India. The me...
UNILATERAL SENSORINEURAL DEAFNESS IN SCHOOL CHILDREN; A CLINICAL AND AUDIOLOGICAL EVALUATION AT A TERTIARY HOSPITAL OF TELANGANA
INTRODUCTION Interpersonal communication, day to day activities, learning language and acquiring grades in the school are important parts in the life of school going children. Unilateral or bilateral Loss of hearing affe...
AN APPROACH TO INTRAOPERATIVE FINDING OF MIRIZZI’S SYNDROME
BACKGROUND Currently various management approaches are described in the literature for Mirrizi’s syndrome. But there are no clear guidelines for the safe management approach for this rare syndrome. Aim of the study- How...
STUDY OF CERVICAL PAP SMEAR STUDY AND ITS UTILITY IN CANCER SCREENING- AN EXPERIENCE IN A TERTIARY CARE HOSPITAL OF TRIPURA, NORTH EASTERN STATE OF INDIA
BACKGROUND Cancer of cervix is a global health problem and is a leading cause of morbidity and mortality of women in India. It is one of the most preventable and curable of all cancers. Simple, noninvasive screening proc...