A Clinical Study to See the Relationship between CNS Tuberculosis and Various Demographic Factors in a Population Attending a Tertiary Hospital in Northern India (Original Study)
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 2
Abstract
Introduction: Tuberculosis is a granulomatous disease caused by Mycobacterium tuberculosis AIM: Tuberculosis is very common in our part of world. Though a lot of study has been done on this topic but regarding CNS tuberculosis we have only few prospective studies available. There is a desperate need for such a study in our part of country. Materials and Methods: The study was conducted in Department of Pathology, in a tertiary care Institute in Northern India. The study was retrospective for a period of 8 years (May 2001 to May 2009) and prospective for a period of 2 years (May 2009 to May 2011). In retrospective the slides of all the CNS tuberculosis cases diagnosed were searched from the records section of the department. In prospective study all cases of histologically proven cases of CNS tuberculosis were included in the study. Age was no bar for inclusion in the study. Patients with features of meningitis were excluded from the study. The clinical details of these patients were noted especially patient particulars, history (present,past & relevant),clinical features& investigations done. Blood and CSF PCR was done for detecting mycobacterium tuberculosis. In cases where there was abscess formation, abscess fluid was sent for PCR. Patients suffering from tubercular meningitis were excluded from this study. Observations: In the present series which included a retrospective study of 8 years and a prospective study of 2 years, a total no of 90 cases of CNS tuberculosis were analysed. The age range for CNS tuberculosis was13-73 years with a mean age of 37.98 years. Age range for brain tuberculosis was 15-65 years with a mean age of 40.63 years. Out of total 90 patients 58(64.4%) were males and 32(35.5%) were females with a male to female ratio of( 1.8:1).In brain tuberculosis 21(65.6%) were males and11(34.3%) were females with a ratio of(1.91:1). The predominant age group was 21-40 years with 40(44.4%) patients falling in this age group. Twelve (13.3%) of the patients were below the age of 20 years and 06(6.66%) patients were above 60 years Summary: It has been observed that prevalence of tuberculosis of CNS is high in this part of country. The age range of our patients was 13-73 years with a mean age of 37.98 years. Male to female ratio was found to be 2:1.Past history of tuberculosis was the major risk factor for development of CNS Tuberculosis. So the emphasis is proper management of every tuberculous patient so that future risk of CNS involvement is minimized
Authors and Affiliations
Basharat Mubeen
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