A Comparative Evaluation of the Addition of Clonidine or Dexmedetomidine to Levobupivacaine at Tertiary Care Centre of Central India
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 4
Abstract
Adjuncts to local anaesthetics for brachial plexus block may enhance the quality and duration of analgesia. Clonidine, an Alpha-2 adrenergic agonist, is known to produce ant nociception and enhance the effect of local anaesthetics when given epidurals, intrathecal or in various peripheral nerve blocks. Levobupivacaine is a local anaesthetic drug belonging to amino amide group. It is the s. enantiomer of bupivacaine. Levobupivacaine has a greater margin of clinical safety with respect to both CVS AND CNS effects as compared to racemic bupivacaine. Dexmedetomidine, a selective α2-adrenoceptor agonist, has been used as an adjuvant during regional and local anaesthesia. The primary end points are the onset and duration of sensory and motor block and duration of analgesia. The purpose of this study was to assess the effect of Clonidine or dexmedetomidine, added to Levobupivacaine in brachial plexus block by supraclavicular approach. Dexmedetomidine (1μg/kg) in combination with 29mL of levobupivacaine (0.5%) hastened onset of sensory and motor block, and improved postoperative analgesia when used in brachial plexus block, without producing any adverse events.
Authors and Affiliations
Dr. Ravi Barde, Dr. Jitendra Zilve
Keywords
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