A COMPARATIVE EVALUATION OF THE EFFICACY OF TRIPLE DRUG THERAPY WITH DUAL DRUG THERAPY IN COPD PATIENTS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2018, Vol 10, Issue 4
Abstract
Objective: The present study was conducted with the objective of analyzing the efficacy of triple-drug combination therapy (formoterol, ciclesonide, tiotropium) by comparing it with double drug combination therapy (formoterol, budesonide).Methods: A prospective observational study was conducted. Sixty patients were enrolled, and divided into two groups of thirty each; one group was treated with the double-drug and the other with a triple drug combination. FEV1 and FVC pre-and post-treatment in either group were assessed spirometrically. Score ranges of 0-10, 11-20 and 21-30 were allotted to mild, moderate and severe categories and results were analyzed statistically.Results: Of the 60 patients recruited, 61-70 y olds constituted the majority (35%) of the population. Males (63.3%) were more in number compared to females (36.6%). Twenty-three of thirty-eight men smoked (60.5%); there were no female smokers. Common symptoms included cough (93.3%), dyspnoea (85%), fever (45%) and haemoptysis (15%). Hypertension accounted for 70% of patient comorbidities, followed by diabetes (60%) and cardiovascular diseases (40%). Three months after treatment with triple therapy, a significant increase in the differences of means of both FEV1 (14.27) and FVC (14.90) values was observed. Further analysis based on score ranges demonstrated that triple therapy administration markedly reduced the number of patients suffering from severe COPD.Conclusion: Our comparative analysis indicated that triple therapy was more effective in improving lung function, enhancing patients’ quality of life (evidenced from score ranges) thereby reducing mortality. While much is known about the greater effectiveness of triple over dual therapy, researchers to formulate the most effective triple therapy are in progress.
Authors and Affiliations
Pathan Amanulla Khan, A. Sujala, B. b. Sarah Nousheen, Ayesha Farhath Fatima, Hibba Tul Ala, A. b. t. Pallavi Reddy
Keywords
Related Articles
- EP ID EP567535
- DOI 10.22159/ijpps.2018v10i4.24529
- Views 104
- Downloads 0
PHARMACOLOGICAL EVALUATION OF RHIZOMES OF ACORUS CALAMUS FOR ANALGESIC ACTIVITY
Objective: To evaluate the analgesic activity of aqueous extract of rhizomes of Acorus calamusin mice.Methods: Analgesic activity of aqueous extracts of A. calamus at different doses were studied using the hot plate meth...
ENDOPHYTIC FUNGI: TREASURE FOR ANTI-CANCEROUS COMPOUNDS
Endophytic fungi that live asymptomatically inside the plant tissues have novel bioactive metabolites exhibiting a variety of biological activities, especially against cancer. This review highlights the research progress...
CORRELATION STUDY OF AGE, DISEASE DURATION, AND ERYTHROCYTE SEDIMENTATION RATE AMONG THE INDONESIAN RHEUMATOID ARTHRITIS PATIENTS
Objective: The present study aims to determine the correlation between age, disease duration, and erythrocyte sedimentation rate (ESR) among the Indonesian rheumatoid arthritis (RA) patients.Methods: The subject was the...
DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING HPTLC METHOD FOR DETERMINATION OF EPERISONE HYDROCHLORIDE IN BULK DRUG
Objective: A new, economical, precise and accurate stability indicating HPTLC method was developed and validated for the determination of Eperisone hydrochloride in bulk drug.Methods: Sample and standard solutions of Epe...
Article Has Been Withdraw From Publication
Article Has Been Withdraw From Publication