A comparative study between efficacy and safety of telmisartan (ARB) and enlapril (ACEI) in hypertensive patients
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2019, Vol 8, Issue 2
Abstract
Background Hypertension is the most common cardiovascular disease that affects about 1 billion individuals worldwide1. It is defined conventionally as sustained increase in blood pressure ≥ 140/90mmHg. In India the prevalence of hypertension is 25% in urban population and 10% in rural population The WHO reports that hypertension is responsible for 62% of cerebrovascular disease and 49% ischemic heart disease with little variation by sex. Aims and objectives To compare the efficacy and adverse effect profile of telmisartan and enalapril maleate in essential hypertensive patients. 2. To compare the incidence of adverse effects in both telmisartan and enalapril groups. Methods This was a prospective, observational study conducted on outpatients attending Medicine OPD in SMC/GGH, Vijayawada. A total of 80 patients were recruited in the study and divided in to two groups with 40 patients in each group. The total period of the study was 3 months. Clinical examination findings, investigations and relevant history were obtained from studied patients and entered in the proforma. Periodic recording of blood pressure was done for every 2,6 and 12weeks. Laboratory investigation were carried out before initiation of therapy and at the end of the study. Results Essential hypertension was more in the age group of 50-55 years accounting for n=24 followed by 40-44yrs which was n=20. After 12 weeks of therapy in essential hypertension group systolic blood pressure was reduction to normal level was 85% with telmisartan and 70% with Enalapril maleate. Diastolic B.P. reduction was 70% with telmisartan and 60% with Enalapril maleate treatment in patients after 12 weeks of treatment. Cough – 2.5% telmisartan group, 10% in Enalapril maleate group, between 10-12 weeks. Rash – observed equally 2.5% in telmisartan group. Conclusion In the present study both telmisartan and enalapril maleate reduced both systolic and diastolic blood pressures in both Groups at 2 weeks, 6 weeks and 12 weeks almost equally. But in terms of adverse effect profile, persistent dry cough was observed in 10% of enalapril maleate treated group and 2.5% in telmisartan treated group. Rash was observed 2.5% with both drugs. Telmisartan is effective and better tolerated than enalapril in the treatment hypertension.
Authors and Affiliations
Dr. Ch. Jhansi Vani
Keywords
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