A COMPARATIVE STUDY OF DEXMEDETOMIDINE AND CLONIDINE IN EPIDURAL ANAESTHESIA WITH ROPIVACAINE FOR LOWER ABDOMINAL AND LOWER LIMB SURGERY
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 11
Abstract
BACKGROUND Epidural anaesthesia using Inj. Ropivacaine results in an effective anaesthesia and postoperative analgesia and addition of adjuvants would be advantageous. Clonidine and dexmedetomidine are α2-agonists used as adjuvants in epidural anaesthesia. Aim of our study was to compare Inj. Dexmedetomidine and Inj. Clonidine added to epidural ropivacaine with respect haemodynamic parameters- heart rate, systolic blood pressure, diastolic blood pressure, motor blockade and sedations scores in patients undergoing lower abdominal and lower limb surgeries. MATERIALS AND METHODS This prospective, randomized, double blind study involved 60 patients of ASA-I, II who were categorized into two groups- GroupRD (n=30) received 1µ/kg Inj. Dexmedetomidine and Group-RC (n=30) received 1 µg/kg Inj. Clonidine. Patients in both groups received 17 ml of Inj. Ropivacaine epidurally. Patients were assessed for sensory block of T10 level, heart rate, systolic blood pressure and diastolic blood pressure, motor blockade using modified Bromage score and sedation score using Ramsay sedation scale. RESULTS Epidural anaesthesia using ropivacaine and adjuvants either clonidine or dexmedetomidine resulted in good sensory analgesia. Haemodynamic parameters with respect to heart rate, systolic blood pressure and diastolic blood pressure were similar between the two groups and were statistically not significant (p >0.05). Sedation scores and modified Bromage scores were statistically significant (p <0.05) for brief intervals of time. CONCLUSION Clonidine and Dexmedetomidine when used as adjuvants to epidural ropivacaine result in stable haemodynamics. Their sedation and motor blockade effects are comparable without significant adverse effects.
Authors and Affiliations
Olugumanu Srinivas Kumar, Pradeep Hosagaoudar, Murali Y. V. , Sreenivas Reddy M
Keywords
Related Articles
- EP ID EP538019
- DOI 10.18410/jebmh/2018/204
- Views 75
- Downloads 0
A STUDY OF SERUM PROCALCITONIN AS A BIOMARKER IN SEPSIS IN A TERTIARY CARE HOSPITAL
BACKGROUND Sepsis is reported to be the most common cause of death in Intensive Care Unit (ICU). It is an increasingly common cause of mortality and morbidity particularly in elderly, immunocompromised and critically ill...
STUDY EVALUATION OF URINE PROTEIN/URINE CREATININE RATIO FOR QUANTIFICATION OF PROTEINURIA IN RAPID AND RELIABLE DIAGNOSIS OF NEPHROTIC SYNDROME
BACKGROUND Nephrotic syndrome is a common renal disease in 2-6-year-old children characterised by proteinuria, hypoalbuminemia, oedema and hypercholesterolemia. Incidence is 2-3 /1 lakh children per year. Without treatme...
A COMPREHENSIVE STUDY ON TRACHEOSTOMY IN A RURAL TERTIARY CARE CENTRE
BACKGROUND Tracheostomy is the procedure in which an opening is created on the anterior wall of the trachea, thereby creating a stoma between the trachea and cervical skin. It is a lifesaving procedure performed to maint...
PREVALENCE OF HYPERTENSIVE RETINOPATHY IN NEWLY DIAGNOSED HYPERTENSIVE PATIENTS
BACKGROUND Systemic hypertension is one of the common problems which is often asymptomatic. Because of this, often we fail to detect hypertension earlier. Purpose of this study is to find out the prevalence of hypertensi...
LOCAL CORTICOSTEROID VS. AUTOLOGOUS BLOOD FOR PLANTAR FASCIITIS
BACKGROUND Plantar fasciitis is the most common cause of heel pain for which professional care is sought. Initially thought of as an inflammatory process, plantar fasciitis is a disorder of degenerative changes in the fa...