A comparative study of esmolol versus dexmedetomidine in attenuation of cardiovascular response following laryngoscopy
Journal Title: Medpulse International Journal of Anesthesiology - Year 2017, Vol 8, Issue 1
Abstract
Objectives: To compare the safety and efficacy of esmolol versus dexmedetomidine in attenuation of cardiovascular response to laryngoscopy. Study design: Randomized controlled clinical trial. Place and duration of study: Rajah Muthiah Medical College, Chidambaram, 2017-2018.Methodology:After acceptance from the department of ethical committee and written informed consent from all patients, a single blinded RCT was conducted on 50 patients (n=50) aged 20–45 years (both sex) of ASA I-II who are posted for elective surgery. They were chosen randomly and allocated into 2 different groups, group A and group B with 25 members in each group. All patients were premedicated with inj.Glycopyrrolate 0.2 mg IM 45 min before induction. Group A received inj. Esmolol 1.5 mg / kgand Group B received Dexmedetomidine 1µg / kg iv. After induction with inj.Thiopentone 5mg/kg and inj. Succinyl choline 2mg/kg, laryngoscopy and ET intubation was done. N2O: O2 mixture- 65:35 and 2% sevoflurane were used as maintenance anaesthesia during intraoperative period.Haemodynamic variables like HR, SBP, DBP and MAP were recorded for both groups before induction, immediately post Intubation, 5 min, 10 min, 15 min, 20 min and 30 min post intubation. Data was analysed and compared. Results: Dexmedetomidine 1µg / kg given intravenously ten minutes preceding induction, obtunded the pressor response post laryngoscopy andETintubation to a statistically significant level compared to Esmolol. Conclusion: Debilitation of pressor response is noted with both Dexmedetomidine and Esmolol. Among the twodrugs Dexmedetomidine 1 µg/kgi.v bolus provides consistent and more effective debilitation than Esmolol 1.5 mg/kg i.v bolus.
Authors and Affiliations
R Gowthaman, M Shanmugavalli
Keywords
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- EP ID EP440549
- DOI 10.26611/1015818
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