A COMPREHENSIVE REVIEW OF PULSATILE DRUG DELIVERY SYSTEMS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 3
Abstract
Pulsatile drug delivery systems are gaining popularity in the field of pharmaceutical formulation, research and development. The prime advantage in this drug delivery is that the drug is released as per the pathophysiological need of the disease. As a result the change of development of drug resistance which is seen in conventional and sustained released formulations can be reduced. This therapy is mainly applicable where sustained action is not required and the drugs are toxic. Basic point of development of this formulation is to find out the circadian rhythms that is a suitable indicator that will trigger the release of drug from the device. Clock genes are the genes that control the circadian rhythms in human physiology. Pulsatile drug delivery systems are promising incase of asthma, cardiovascular diseases, peptic ulcers, arthritis, and hypercholesterolemic conditions.
Authors and Affiliations
Bhargavi Rompicharla , Prabha Suria , Tabasum Md
Keywords
Related Articles
- EP ID EP124849
- DOI -
- Views 121
- Downloads 0
ANALYSES OF THE EFFECTS OF SWEDISH BITTERS ON SELECTED METABOLIC PROFILES
Swedish Bitters® is a traditional herbal tonic that has detoxification potential and has been claimed to contribute to weight loss and normal functioning of body organs. In this study Swedish Bitters was analyzed for its...
ROLE OF BETA LACTAMASES IN ANTIBIOTIC RESISTANCE: A REVIEW
Penicillin, the first β-lactam antibiotic was introduced into clinical practice in 1940s. Since then a large number of different β-lactam antibiotics including penicillins, cephalosporins, monobactam and carbapenems have...
DNA DAMAGE PROTECTION AND HAEMOLYTIC ACTIVITY OF ISOLONGIFOLENE
In this study a Sesquiterpene, Isolongifolene of Murraya koenigii tested for its DNA protecting, genotoxicity and haemolytic activity. DNA Protecting activity was tested against genomic DNA using various concentrations o...
THERAPEUTIC APPROACH TO CANCER BY VEGETABLES WITH ANTIOXIDANT ACTIVITY
Cancer is the second leading cause of human deaths in the world. However, the potential treatment of cancer is still under investigation. In fact, the plants may occupy a good place in the treatment of cancer with no ill...
A NEW OXOTIRUCALLOIC ACID FROM THE STEM BARK OF MANGIFERA INDICA VAR. “LANGRA”
Phytochemical investigation of the ethanolic extract of the stem bark of Mangifera indica variety “Langra” yielded three new phytoconstituents characterized as n-docosan-18′-one-22′-ol-1′-yl hexanoate, 20(R), 24(R)-3-oxo...