A Cross Sectional Study of Thyroid Function Abnormalities in Liver Diseases in a General Hospital
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 1
Abstract
Introduction: A complex relationship exists between the thyroid gland and the liver in both health and disease. Many studies have been carried out on liver disease patients assessing their thyroid status, mostly in European countries. Most of these studies are limited by the number of patients in these studies. This study tries to find out the relationship between thyroid function and chronic liver disease in a general hospital in India. Materials and methods: This hospital-based cross-sectional study was conducted in patients admitted in the ward under the Department of General Medicine, Kamineni Academy of Medical Sciences and Research Centre, Hyderabad. A total of 200 subjects were selected after explaining the purpose of the study and the procedure in detail and after obtaining their consent in written format. Data collection was done by history, clinical examination and investigations. With physical examination aided by abdominal imaging, patients who had ascites were graded into mild, moderate and severe refractory ascites. Hepatic encephalopathy was graded into grade 0 to 4 according to West Haven criteria. Results: 24.6% of the study population showed abnormalities in thyroid function tests. The commonest was sick euthyroid syndrome in 18% of patients. Subclinical hypothyroidism was present in 4.7% of patients. Thyroid hormone levels had significant correlation with various liver function indices. Serum levels of total T3 and free T3 had significant positive correlation with serum albumin level and negative correlation with serum bilirubin and INR value. Free T4 had a weak negative correlation with serum bilirubin. Serum T3 and Free T3 were found to be decreased in patients with hepatic encephalopathy and ascites according to the severity. When severity of liver dysfunction was assessed using Child-Pugh score, it was found that there was statistically significant decrease in serum T3 and FT3 levels as the severity of liver dysfunction increased. Conclusion: Chronic liver diseases were associated with abnormalities in thyroid function tests, although most of the patients remained clinically euthyroid. Serum T3 and FT3 levels had an inverse correlation with the severity of liver dysfunction.
Authors and Affiliations
Dr. Panuganti Ratnachary, Dr. K. Sudha Rani
Keywords
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- EP ID EP434803
- DOI 10.9790/0853-1801085558.
- Views 70
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