A Decade of Invasive Candida Infection in Neonates: A Retrospective Study at a Tertiary Neonatal Intensive Care Unit in Thailand (2008–2018)
Journal Title: Vajira Medical Journal: Journal of Urban Medicine - Year 2024, Vol 68, Issue 2
Abstract
OBJECTIVE: To determine the epidemiology of invasive candida infection in the neonatal intensive care unit (NICU) at a tertiary care center in Thailand over 10 years. METHODS: A retrospective descriptive study was conducted. Participants were enrolled from all neonates diagnosed with invasive candidiasis infection (ICI) in Vajira Hospital between 2008 and 2018. Demographic data, microbiological results, and neonatal outcomes were reviewed. RESULTS: During the study period, 9,031 neonates were admitted to the NICU. A total of 14 neonates were diagnosed with ICI, giving a prevalence of 1.5 cases per 1,000 infants admitted to the level II and III NICU. The median (IQR) gestational age and birth weight were 28.5 weeks (27.0, 31.0) and 1,053 g (850.0, 1,586.5), respectively. In all, 10 (71.4%) and 8 (57.1%) neonates had positive blood and urine cultures, respectively. All infants had negative cerebrospinal fluid cultures. Among 14 neonates diagnosed with ICI, 7 (50.0%) neonates had positive cultures for Candida albicans. The overall mortality rate of neonates with ICI was 21.4%. CONCLUSION: ICI exhibits a low incidence rate within Vajira Hospital. This occurrence is demonstrably associated with prematurity, extremely low birth weight infants, and a demonstrably high mortality rate.
Authors and Affiliations
Pathaporn Prempraphan, Manisara Puengwongtrakul
Keywords
Related Articles
- EP ID EP738923
- DOI http://dx.doi.org/10.62691/vmj.2024.267005
- Views 67
- Downloads 1
Caring at Cardiology Clinic versus Heart Failure Clinic: Impact of Implementation of GuidelineDirected Medical Therapy in Heart Failure with Reduced Ejection Fraction in Outcomes of Death and Heart Failure Readmission
OBJECTIVE: This study aimed to determine whether the heart failure (HF) clinic setting can improve guideline-directed medical therapy (GDMT) use and reduce HF readmission and mortality rates in patients with heart failur...
Association between Hand Grip Strength and Risk of Malnutrition in Elderly at Out-Patient Clinic, Faculty of Medicine, Vajira Hospital
Objectives: To study the optimal cut-off point of hand grip strength for evaluation risk of malnutrition, and factors associated with malnutrition in elderly out-patient clinic, Faculty of Medicine Vajira Hospital. Meth...
Chief Complaints, Clinical Characteristics, and Outcomes of Emergency Department Visit among Pediatric Cancer Patients: A Single-Center Experience
OBJECTIVE: The aim of this study was to examine the chief complaints and clinical characteristics, outcomes, and associated factors of pediatric cancer patients who present at the emergency department (ED). METHODS: A r...
Glycopyrrolate to Prevent Spinal Anesthesia Induced Hypotension in Pregnant-Women Who Underwent Cesarean Section: Randomized Controlled Trial
Objective: A primary outcome was to compare an incidence of hypotension following an administration of glycopyrrolate versus a placebo before commencing a spinal anesthesia in pregnant-women. Simultaneously, a bradycardi...
A Decade of Invasive Candida Infection in Neonates: A Retrospective Study at a Tertiary Neonatal Intensive Care Unit in Thailand (2008–2018)
OBJECTIVE: To determine the epidemiology of invasive candida infection in the neonatal intensive care unit (NICU) at a tertiary care center in Thailand over 10 years. METHODS: A retrospective descriptive study was condu...