A Decade of Invasive Candida Infection in Neonates: A Retrospective Study at a Tertiary Neonatal Intensive Care Unit in Thailand (2008–2018)
Journal Title: Vajira Medical Journal: Journal of Urban Medicine - Year 2024, Vol 68, Issue 2
Abstract
OBJECTIVE: To determine the epidemiology of invasive candida infection in the neonatal intensive care unit (NICU) at a tertiary care center in Thailand over 10 years. METHODS: A retrospective descriptive study was conducted. Participants were enrolled from all neonates diagnosed with invasive candidiasis infection (ICI) in Vajira Hospital between 2008 and 2018. Demographic data, microbiological results, and neonatal outcomes were reviewed. RESULTS: During the study period, 9,031 neonates were admitted to the NICU. A total of 14 neonates were diagnosed with ICI, giving a prevalence of 1.5 cases per 1,000 infants admitted to the level II and III NICU. The median (IQR) gestational age and birth weight were 28.5 weeks (27.0, 31.0) and 1,053 g (850.0, 1,586.5), respectively. In all, 10 (71.4%) and 8 (57.1%) neonates had positive blood and urine cultures, respectively. All infants had negative cerebrospinal fluid cultures. Among 14 neonates diagnosed with ICI, 7 (50.0%) neonates had positive cultures for Candida albicans. The overall mortality rate of neonates with ICI was 21.4%. CONCLUSION: ICI exhibits a low incidence rate within Vajira Hospital. This occurrence is demonstrably associated with prematurity, extremely low birth weight infants, and a demonstrably high mortality rate.
Authors and Affiliations
Pathaporn Prempraphan, Manisara Puengwongtrakul
Keywords
Related Articles
- EP ID EP738923
- DOI http://dx.doi.org/10.62691/vmj.2024.267005
- Views 66
- Downloads 1
A 5-Year-Retrospective Review: The Clinical Outcome between Adequate and Inadequate of Initial Antibiotics Treatment in Pediatric Patients, Vajira Hospital
OBJECTIVE: The results of adequate and inadequate empirical antibiotics remain unclear. This study aimed to evaluate the results of using adequate and inadequate empirical antibiotics. METHODS: A retrospective cohort an...
A Sternocleidomastoid Mass: An Unusual Manifestation of Lymphoma
Most non-Hodgkin lymphoma patients present with nodal involvement; nevertheless, extra-nodal involvement accounts for 20-30% of the cases. Common extra-nodal sites are gastrointestinal tract also head and neck region. In...
The Effect of a High Monosodium Glutamate Diet in Inducing Changes in Microbiota Diversity and Kidney Pathology in Hamsters Infected with Opisthorchis viverrini
OBJECTIVE: To investigate the effect of a combination of a high dose of monosodium glutamate (MSG) and chronic Opisthorchis viverrini (O. viverrini) infection on kidney pathology and microbiota changes compared to either...
Rate and Predictors of Postoperative Respiratory Complications Following Adenotonsillectomy in Children with Obstructive Sleep Apnea
OBJECTIVE: This study aimed to determine the rate and risk factors of postoperative respiratory complications in children with obstructive sleep apnea (OSA) who underwent adenotonsillectomy. METHODS: A retrospective stu...
Prevalence of Vertical Transmission of HIV at Faculty of Medicine Vajira Hospital
Objective: To study the prevalence of vertical transmission of HIV at Faculty of Medicine Vajira Hospital. Methods: Data from medical records of children born from an HIV-infected mother at Faculty of Medicine Vajira Ho...