A facile synthesis and antibacterial screening of some new 4- Thiazolidinone derivatives
Journal Title: IOSR Journal of Applied Chemistry (IOSR-JAC) - Year 2018, Vol 11, Issue 8
Abstract
Efficient syntheses of 4-thiazolidinone are affected by reaction of 6-methoxy-2-acetyl naphthalene and 4-methoxy-2-hydroxy benzaldehyde to give chalcone. This on further reaction with guanidine nitrite gives Amino Pyrimidine derivative. This amino Pyrimidine derivative treated with methyl chloroformate, hydrazine hydrate and various substituted aromatic aldehydes respectively yielded various Schiff bases. The reaction of various substituted Schiff bases with thioglycolic acid gives corresponding 4-thiozolidinone derivatives The various synthesized compounds were assigned on the bases of elemental analysis, IR and 1H NMR spectral data. The compounds are evaluated for their antibacterial activity.
Authors and Affiliations
Chirag K. Naik, Vikas A. Desai
Keywords
Related Articles
- EP ID EP414382
- DOI 10.9790/5736-1108015559.
- Views 174
- Downloads 0
To Compare Formation And Stability Of complexes Of Some Transition Metal Ions With Amino Acids With Stability Constant.
Chemistry ofProteins which are the most complex substances known to man is one of the great challenges in modern science. In the present work peptides of amino acid were used to study metal-ligand stability constants. Va...
The Effect of pH on formation of Demi-macrocycles of N2O2 with complexes Cr (II) Fe (II) and Co (II) ions”
The kinetic measurements was carried out under pseudo first-order conditions are followed in different pH range kinetic integration and graphical method at different pH range 6.55, 7.0 and 9.2 at constant acetate buffer...
Synthesis of photoconductingcarbazole Based Polybenzoxazines.
N-(9-ethyl carbazolyl) benzoxazine was synthesized by the reaction of 3-amino-9-ethyl Carbazole with paraformaldehyde and 4- methyl phenol under reflux in the solvent medium of toluene. The corresponding polybenzoxazine...
Biosynthesis, Characterization and Anti-Cancer Activities of Thorium Nanoparticles Using Ananas Comosus (Pineapple) Extract
Chemicals typically available in plants have the capability to reduce thorium and to create thorium nanoparticles. We report the preparation of thorium nanoparticles with sizes between 1µm to 100 nm from thorium nitrate...
Synthesis, Spectroscopic and Physico-chemical Studies and X-Ray Structure determination of a Metal transitions Complexes from ligand generated by benzoylpyridine
Metals transition complexes, [M(Li )(H2O)2] . (X)2 . (H2O)n, (M= Mn, Ni, Cu or Zn; i=1 or 2; n=0, ½, 1 or 2) where L1 is the neutral tridentate Schiff base (E)-N 1 -(2-(phenyl(pyridin-2-yl)methyleneamino)ethyl)ethane1,2-...