A Histopathological Study on Invasive Ductal Carcinoma Breast with Respect to ER/PR Status and Mast Cell Distribution
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 10
Abstract
Introduction: When a carcinoma develops our immunity plays a major role in fighting against tumor cells. Mast cells which play a major role in our innate immunity are also found to get activated in a developing tumor. So far only few studies have been conducted on the role of mast cell in carcinoma breast which have shown the cytolytic activity of these on tumor cells and their relationship in response to hormone receptor status. Aim: To study the histopathological characteristics of invasive ductal carcinoma breast. and mast cell count in them and their relationship with Estrogen & Progesterone receptor status. Materials and Methods: We did a descriptive histopathological study on the specimens of modified radical mastectomy received in the Department of Pathology, Government Medical College, Thiruvananthapuram from 1st January 2012 to 2014. Histopathological characteristics of each case with respect to their ER/PR status was studied. Mast cell were stained using special stains and counted. Data was statistically analysed with SPSS software using Univariate analysis and chi square test to detect the significance of mast cell presence with receptor status in invasive ductal carcinoma breast. Results: Out of total 150 cases the mast cells were present in 56 cases (37.3%) and were absent in 94 cases (62.7%). The relationship between presence of mast cells and estrogen and progesterone receptor positivity was found to be stastically insignificant as the p-value was more than 0.05. Thus there was no significant relationship between estrogen and progesterone receptor status with the presence of mast cells. Conclusions: The present study showed that there is no significant relationship between presence of mast cells in peritumoral tissue and the hormonal status of the patient. So as per this study mast cell presence cannot be suggested as a definitive cheap easily assessable prognostic factor in carcinoma breast. Newer modalities for detection of new prognostic indicators can help in implementation of adjuvant therapies in a patient with ductal carcinoma breast.
Authors and Affiliations
Dr Annu Sajeev
Keywords
Related Articles
- EP ID EP529651
- DOI -
- Views 100
- Downloads 0
Postoperative Wound Infection in Surgical Ward
The principle aim of this study was to determine the incidence of post-operative wound infection and the common pathogens responsible for SSI and their sensitivity to antibiotics, thereby modifying the approach for its m...
Comparative Study of Stoppa’s Repair by Pfannensteil Incision Versus Lichtenstein Technique for Management of Bilateral Inguinal Hernia
Background: Hernia repair is one of the most commonly performed general surgical procedures worldwide. Today, Stoppa’s repair has been considered as an alternative to Lichtenstein’s tension free mesh hernioplasty in the...
Dextrose Treats Optic Neuritis
The sphenopalatine ganglion—also known as pterygopalatine ganglion, Meckel’s ganglion, Sluder’s ganglion and nasal ganglion—is the largest of the four parasympathetic ganglia associated with the trigeminal nerve. It is c...
Study of Prevalence of Diabetes Mellitus among Patients Suffering from Thyroid Disease
Objectives: To study the prevalence of Diabetes Mellitus in patients suffering from thyroid disorders Methodology: This study was conducted in KIMS hospital Bengaluru and it was a prospective observational study. The pat...
Prevalence of Hyperhomocysteinemia among Pre-Eclampsia Patients of A Tertiary Referral Hospital in South India
Introduction: Pre-eclampsia is a pregnancy-specific multisystem disorder and is a leading cause of maternal and fetal morbidity and mortality. Several studies have provided evidences that indicate the involvement of hype...