A Modeling and Simulation Framework for Adverse Events in Erlotinib-Treated Non-Small-Cell Lung Cancer Patients
Journal Title: The AAPS Journal - Year 2015, Vol 17, Issue 6
Abstract
The online version of this article (doi:10.1208/s12248-015-9815-8) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Ahmed Abbas Suleiman, Sebastian Frechen, Matthias Scheffler, Thomas Zander, Lucia Nogova, Martin Kocher, Ulrich Jaehde, Jürgen Wolf, Uwe Fuhr
Stereoselective pharmacokinetics of ifosfamide in male and female rats
The stereoselective pharmacokinetics of ifosfamide (IF) were investigated in male and female Sprague-Dawley rats. Following intravenous administration of IF deuterium-labeled pseudoracemates into rats at 40 mg/kg, IF ena...
Quantitative Prediction of Human Pharmacokinetics for mAbs Exhibiting Target-Mediated Disposition
The online version of this article (doi:10.1208/s12248-014-9690-8) contains supplementary material, which is available to authorized users.
The chinchilla microdialysis model for the study of antibiotic distribution to middle ear fluid
In cases of slow or limited penetration of an antibiotic to the site of infection such as in acute otitis media (the middle ear), plasma levels of the agent may not reflect the concentrations that are relevant in determi...
Permeability Comparison between Hepatocyte and Low Efflux MDCKII Cell Monolayer
Determination of passive permeability is not only important for predicting oral absorption and brain penetration, but also for accurately predicting hepatic clearance. High throughput (HT) measurement of passive permeabi...
Molecular Targets of Dietary Phenethyl Isothiocyanate and Sulforaphane for Cancer Chemoprevention
Development of cancer is a long-term and multistep process which comprises initiation, progression, and promotion stages of carcinogenesis. Conceivably, it can be targeted and interrupted along these different stages. In...