A modern view of the pathogenesis of allergic contact dermatitis and the prospect of studying the nature of contact allergy
Journal Title: Український журнал дерматології, венерології, косметології - Year 2018, Vol 0, Issue 4
Abstract
Objective — to increase the effectiveness of the diagnosis and treatment of allergic contact dermatitis, taking into account the analysis of literary data on the systemic and local immune response of the organism and the evaluation of the results of previous own clinical and laboratory studies, including the modern allergy PATCH-TEST and the immunohistochemical features of the skin cellular lesion. in patients with this dermatosis. Materials and methods. The analysis and systematization of modern publications on the pathogenesis of allergic contact dermatitis has been carried out. There is a lack at the present stage of clear representations of the pathogenesis of atopic contact dermatitis, as well as the importance of assessing the immunological state of the skin as a primary-affected organ to understand the pathogenesis of contact allergy. The methodology and criteria for the further implementation of the modern allergic PATCH-TEST examination of patients with allergic contact dermatitis and immunohistochemical studies of morphological characteristics of immunocompetent cells in skin infiltration, as well as the study of the dynamics of quantitative and qualitative indices of different populations of T-lymphocytes and cytokine concentration at the system level in these patients. Results and discussion. Taking into account the previous results of conducting the modern allergy PATCH-TEST and studying the immunohistochemical features of the cellular lesion in the skin of patients with allergic contact dermatitis, as well as the results of the study of the dynamics of different populations of T-lymphocytes (T-cells of memory, naive and activated T-helper cells, regulatory and cytotoxic T cells, αβ and γδ-T-lymphocytes), the latest data on the pathogenesis of this dermatosis will be obtained and an optimized correction of pathogenetic therapy is proposed. Conclusions. The preliminary results of the conducted studies indicate a correlation between the dynamics of the systemic and local natural and acquired cellular immunity in patients with allergic contact dermatitis. Further in-depth study and analysis of relevant indicators will contribute to the development of diagnostic and treatment algorithm for the diagnosis and management of patients with various forms and stages of allergic contact dermatitis.
Authors and Affiliations
V. V. Hiliuk
Keywords
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- EP ID EP455197
- DOI 10.30978/UJDVK2018-4-81
- Views 113
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