A molecular approach for the detection of Hepatitis B virus Genotyping it's clinical importance by using PCR in a Teaching Hospital.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 10
Abstract
Objectives and Aim We performed a study on Seroprevalance, risk factors and HBV genotypes among the patients attending a tertiary care hospital in India. Background: Globally, Hepatitis B is one of the most common infectious diseases. It is ranked by the WHO as one of the top ten killers. The virus is responsible for approximately 1.5 million deaths worldwide in each year, two thirds of which are attributable to primary Hepatocellular carcinoma following HBV infection. About 360 million people are estimated to be chronically infected with HBV. Method -- 284sampleswerepositiveforHBsAgbyELISA.PCRamplificationwasdonefordetectionof‘S’geneandthesesampleswe resubjectedtofurtherGenotyping Results-TheseroprevalenceofHepatitisBinfectioninourstudywas6%, associated with blood transfusion as the major risk factor. ThemostpredominantgenotypewasC-66(50.8%)
Authors and Affiliations
Dr Deepak kumar, Dr Samreen Khan
Keywords
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- EP ID EP402606
- DOI 10.9790/0853-1710100817.
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