A new equivalence based metric for predictive check to qualify mixed-effects models

Journal Title: The AAPS Journal - Year 2005, Vol 7, Issue 3

Abstract

Authors and Affiliations

Pravin R. Jadhav, Jogarao V. S. Gobburu

Keywords

Related Articles

Maturation and growth of renal function: Dosing renally cleared drugs in children

A model was developed that characterized the maturation and growth of the renal function parameters (RFPs) glomerular filtration rate (GF), active tubular secretion (AS), and renal plasma flow (QR). Published RFP values...

A survey of population analysis methods and software for complex pharmacokinetic and pharmacodynamic models with examples

An overview is provided of the present population analysis methods and an assessment of which software packages are most appropriate for various PK/PD modeling problems. Four PK/PD example problems were solved using the...

Pharmacokinetics in mice implanted with xenografted tumors after intravenous administration of tasidotin (ILX651) or its carboxylate metabolite

The pharmacokinetics of tasidotin (ILX651), a depsipeptide currently in phase II for the treatment of advanced solid tumors, and tasidotin-C-carboxylate, the main metabolite, were characterized in male nude mice implante...

Population Pharmacodynamic Parameter Estimation from Sparse Sampling: Effect of Sigmoidicity on Parameter Estimates

The objective of this stimulation study was to evaluate effect of simoidicity of the concentration–effect (C–E) relationship on the efficiency of population parameter estimation from sparse sampling and i...

Hemoglobin-derived Peptides as Novel Type of Bioactive Signaling Molecules

Most bioactive peptides are generated by proteolytic cleavage of large precursor proteins followed by storage in secretory vesicles from where they are released upon cell stimulation. Examples of such bioactive peptides...

Download PDF file
  • EP ID EP681886
  • DOI  10.1208/aapsj070353
  • Views 89
  • Downloads 0

How To Cite

Pravin R. Jadhav, Jogarao V. S. Gobburu (2005). A new equivalence based metric for predictive check to qualify mixed-effects models. The AAPS Journal, 7(3), -. https://www.europub.co.uk/articles/-A-681886