A NOVEL APPROCH: PULSATILE DRUG DELIVERY SYSTEM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 9
Abstract
Pulsatile drug delivery system (PDDS) is useful in the treatment of disease, in which drug availability is timed to match rhythms of disease, in order to optimize therapeutic effect and minimize side effects. PDDS have attracted attraction because of their multiple benefits over conventional dosage forms. The specific time that patients take their medication is very important as it has significant impact on success of treatment. If symptoms of a disease display circadian variation, drug release should also vary over time. Diseases wherein pulsatile drug delivery systems are promising include cardiovascular diseases, arthritis, asthma, cancer, hypercholesterolemia, duodenal ulcer, neurological disorders and diabetes. In pursuit of pulsatile release, various design strategies have been proposed, mainly including time controlling, stimuli induced, externally regulated and multiparticulate formulations. This review will cover methods that have been developed to control drug delivery profile with different polymeric systems like time controlling, internal stimuli induced (temperature induced and chemical stimuli-induced), and external induced (magnetic fields, ultrasound, electric fields and light stimulation) and multiparticulate system. Pulsatile drug delivery systems have the potential to bring new developments in the therapy of many diseases.
Authors and Affiliations
Rajesh Asija , Jaimin Patel , Sangeeta Asija
Keywords
Related Articles
- EP ID EP92826
- DOI -
- Views 120
- Downloads 0
ISOLATION IPG3-1 AND IPG3-3, ENDOPHYTIC FUNGI FROM DELIMA (PUNICA GRANATUM LINN.) TWIGS AND IN VITRO ASSESSMENT OF THEIR ANTI MICROBIAL ACTIVITY
IPG3-1,2,3,4,5 were endophytic fungi isolated from Delima twigs via direct seed inoculation on Potato Dextrose Agar (PDA). Macroscopic identification of the isolates showed clearly that IPG3-3 and 4 have radial wrinkles...
ERGOGENIC AIDS: BOON OR BANE TO MANKIND?
Ergogenics have revolutionized the field of sports and therapeutics. These mainly include mechanical, nutritional, physiological, psychological and pharmacological ergogenic methods. Nutritionally, ergogenic aids are uti...
PHYTOCHEMICAL SCREENING AND ANTIBACTERIAL ACTIVITY FROM NERIUM OLEANDER AND EVALUVATE THEIR PLANT MEDIATED NANOPARTICLE SYNTHESIS
Phytochemical and antibacterial activity of essential oils obtained from Nerium oleander leaf with the help of three different extracts like ethanol, Methanol, and acetone. In this aqueous leaf extracts confirms the pres...
DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF PROPRANOLOL HYDROCHLORIDE AND FLUNARIZINE DIHYDROCHLORIDE IN BULK AND COMBINED DOSAGE FORM
The first order derivative of UV spectrometry method for simultaneous determination of Propranolol hydrochloride (PRO) and Flunarizine dihydrochloride (FLU) in pure bulk drug and combined dosage form was found to be simp...
EFFECTS OF METHANOLIC EXTRACT OF ALPINIA GALANGA FROM MANIPUR (INDIA) ON UTERUS OF OVARIECTOMISED C3H ALBINO MICE
Methanolic extract of shade dried rhizome of Alpinia galanga (MAGE) was prepared using Soxhlet apparatus through a minimal of 18 hrs running. Working doses of the MAGE were determined after LD50 study selecting two dos...