A NOVEL COPPER-CATALYZED C-C BOND CLEAVAGE OF ARYL (HETEROARYL) ALKYL KETONES FOR C-N BOND FORMATION
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2017, Vol 4, Issue 2
Abstract
A direct generation of amide from aryl (heteroaryl) alkyl ketones has been accomplished via copper(II) catalyzed C-C bond cleavage in the presence of diisopropylamine at moderate temperature. The transformation steps for amide formation comprise catalytic generation of α-bromo carbonyl species followed by nucleophilic displacement of bromide with sodium azide in the presence of diisopropylamine. The final step involves the formation of imine by heating in situ followed by hydrolysis to give the related amide.
Authors and Affiliations
Mehdi Bakavoli
Keywords
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