A Pilot Study on Vitamin D and Respiratory Diseases in Southern Part of India
Journal Title: International Journal of Current Research and Review - Year 2017, Vol 9, Issue 7
Abstract
Background: Over the past decade, interest has grown in the role of vitamin D in many nonskeletal medical conditions, such as cancer, diabetes mellitus, and cardiovascular diseases including respiratory infection. Emerging evidence indicates that vitamin D-mediated innate immunity is important in host defenses against respiratory tract pathogens. There are few researches linking vitamin D to various immune-related conditions, including asthma, allergic rhinitis, although the pattern of this relationship is still yet to establish. This study was done to understand the role of vitamin D levels in patients with respiratory tract infection in the southern part of India. Materials and Methods: After obtaining ethical clearance from the institutional ethics committee retrospective study was conducted. A total of 125 Patients with respiratory complaints like bronchial asthma, chronic obstructive pulmonary disease, and allergic rhinitis were included.100 healthy volunteers were included as a control. Total serum vitamin D assay was measured by ECLIA method. Serum IgE levels were measured using COBAS 6001 analyzer. Statistical analysis was done using SPSS 16.0 version. Results: Vitamin D level was highly significantly lower(p <0.01) in the respiratory diseases group compared with the control group, and the total IgE level was highly significantly higher in the asthmatic groups compared with the control group. Conclusion: Deficiency of Vitamin D levels may predispose to respiratory infections. Supplementation with vitamin D, exposure to sun light and increased physical activity may decrease the predisposition to respiratory tract infection.
Authors and Affiliations
Dr. Vijetha Shenoy Belle
Keywords
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