A Prospective, Double Blind, Randomized Clinical Study on Effect of Oral Clonidine Premedication on the Induction Dose of Intravenous Thiopentone Sodium
Journal Title: International Journal of Medical Science And Advanced Clinical Research (IJMACR) - Year 2018, Vol 1, Issue 6
Abstract
Background: Preanaesthetic medication significantly modulates intraoperative requirement of anaesthetic agents such as the i.v. anaesthetic Thiopentone sodium. Objectives: A prospective, randomised, double blind, was done to evaluate the effect of oral Clonidine premedication on the induction dose of Thiopentone sodium. To study hemodynamic and sedative effects of oral Clonidine. Methods: The study was done on 60 patients of age group 18-60 years and ASA grade I and II scheduled for elective surgeries under general anaesthesia. After obtaining a well informed consent, these patients were randomly divided in two groups A and B with 30 patients each according to whether they receive placebo or Clonidine 4µg/kg orally, 90 min prior to induction as premedication. Results and interpretation: Clinical parameters as per module of the study were recorded and tabulated for statistical analysis and interpretation was discussed in detail to draw conclusions. Induction dose of Thiopentone was 5.63±0.46 mg/kg in group A and 4.3±0.22 mg/kg .The mean arterial blood pressure (MABP) and pulse rate were lower in groups receiving Clonidine. Administration of oral Clonidine in a dose of 4µg/kg given 90 min before induction decreases the induction dose of Thiopentone sodium. Clonidine produces clinically significant reduction in sedation score with hemodynamic stability. No significant side effect was seen after premedication with oral Clonidine. Conclusion: There were no complications or adverse effects during the study period. The oral Clonidine 4µg/kg seems to be better choice for premedication to decrease the induction dose of intravenous Thiopentone sodium.
Authors and Affiliations
Dr. Chandrapal Kumar Bhagat
Keywords
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