A PROSPECTIVE OBSERVATIONAL STUDY ON COMPARISON OF LURASIDONE VERSUS ARIPIPRAZOLE BASED ON SERUM PROLACTIN LEVELS IN A TERTIARY CARE TEACHING HOSPITAL
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2019, Vol 6, Issue 30
Abstract
BACKGROUND We wanted to determine and compare the serum prolactin levels in lurasidone, and aripiprazole drug administered psychiatric patients. METHODS A hospital-based prospective observational study was done in the psychiatric department, RIMS, Kadapa for a period of 06 months (i.e., from Sept. 2018 to Feb. 2019). Patients receiving drugs (Lurasidone/Aripiprazole) were enrolled in our study. Patients in the age group 20-60 years were recruited. Consecutive sampling method was followed during the study procedure. 300 patients were recruited according to study criteria. Ethical approval was obtained from IEC. After taking the informed consent from the patient, data collection form was designed accordingly and given to patients to collect patients’ complete data. Collected data was analysed and interpreted by using the SPSS/Graph Pad Prism/Chi-Square Test. RESULTS We have recruited 300 patients with 150 patients in each group. We have analysed the blood samples of the patients for serum prolactin levels. We have reviewed the patients three times and we have found the mean and standard deviation of each drug in every review. We have analysed the serum prolactin levels based on gender and age differences. And we have compared the other ADR's of the two drugs based on gender differences. And we have also compared the serum prolactin levels of each drug from their base line to third review. CONCLUSIONS From the data collected after each review, it can be concluded that Aripiprazole is a safe drug compared to lurasidone. After assessing the serum prolactin levels, we noted that lurasidone increased prolactin levels dramatically in females and adult patients with age between 25 to 38.5 years. After the collection of statistical data, it can be concluded that Aripiprazole is the safer antipsychotic drug.
Authors and Affiliations
Venkata Ramudu R. , Ramya Sunayana A. , Pavan Kumar Reddy M. V. , Jyothsna G. , Sree Harinadh K.
Keywords
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- EP ID EP670374
- DOI 10.18410/jebmh/2019/418
- Views 92
- Downloads 0
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