A Prospective, Randomized Controlled Trial of Noninvasive Ventilation in Acute Exacerbation of Asthma in Children
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 11
Abstract
Objective: To compare the benefits of noninvasive ventilation (NIV) plus standard therapy vs standard therapy alone in children with acute exacerbation of asthma. Design: Randomized control trial. Setting: Tertiary care Pediatric Intensive Care Unit (PICU), duration of study from October 2014 to September 2016. Participants: Three month to twelve years with acute severe asthma (<24 hours) with initial Becker Score >7 were eligible for this study. Interventions: The study group received NIV under inspiratory positive airway pressure ranging between 10 cm - 18 cm H2O, expiratory positive airway pressure between 4 cm - 12 cm H2O. Vital signs, PO2, PCO2, pH, SPO2 , becker score were recorded at the start, 1, 2, 4, 12, 24, and 48 hrs into the study. Result: Heart rate after four hour and twelve hour and respiratory rate after two hour of treatment were significantly lower compared with admission (p = 0.0001 and p = 0.0294, respectively). With NIV, PO2 at four hour, SPO2 at two hour improved significantly. The endotracheal intubation was significantly lower (22%) in the NIV group than in the control group (45%; p = 0.01698).There was significant difference in length of stay in PICU (p= 0.0109) and hospital (p = 0.0115). Conclusion: NIV seems to afford these children protection from endotracheal intubation and reduced in length of stay in PICU and hospital.
Authors and Affiliations
Dr Sudipta Ghorai MBBS
Effect of Mechanical Closure of Dead Space on Seroma Formation in Modified Radical Mastectomy
Breast carcinoma is a common malignancy among women and the most common of complications associated with modified radical mastectomy is the formation of seroma. Various methods have been tried to reduce the incidence of...
A Correlative Study of Dengue Fever and Cardiac Enzymes
Abstract
A Study of Distress and Well-Being among Mothers of Children with ADHD and AUTISM in Rural, Coimbatore Tamilnadu
Number of studies has investigated about psychological distress of mothers of children with ADHD and AUTISM. Mothers of children with ADHD and AUTISM often experience greater stress and emotional demands. Mothers have to...
Full Time Occlusion: Still a Good Option in Older Age Amblyopia
Materials and Methods: This was a retrospective consecutive case series analysis of children treated for amblyopia at a tertiary care center in squint clinic. All children were advised and received full time occlusion (F...
Foetal Outcomes in Pregnancies with Hepatic Dysfunction
Hepatic dysfunction occurring in pregnancy is a potential cause for adverse foetal outcomes. Aim: To assess the foetal outcomes in pregnancies with hepatic dysfunction. Material and Methods: 100 antenatal patients admitt...