A prospective, randomized controlled trial of sanguisorba oil in the treatment of tamoxifen-related vaginitis in breast cancer patients
Journal Title: Traditional Medicine Research - Year 2016, Vol 1, Issue 4
Abstract
This study provides further insights into the clinical efficacy of sanguisorba oil in the treatment of tamoxifen-related (TAM) vaginitis in breast cancer patients. Sanguisorba oil for external use was effective in the treatment TAM related vaginitis and/or urinary irritation in breast cancer patients. External use of Sanguisorba oil improves the compliance of breast cancer patients with TAM-related vaginitis, and this should be promoted in clinical. Objective: To evaluate the clinical efficacy of sanguisorba oil in the treatment of tamoxifen-related (TAM) vaginitis in breast cancer patients. Methods: This prospective, randomized controlled trial (from April 2012 to April 2015) included 112 breast cancer patients with TAM-related vaginitis. Patients were randomized 1:1 to the sanguisorba oil group or control group. Patients in the sanguisorba oil group were treated with conventional basic therapy followed by 2g sanguisorba oil for external application after cleaning the vulva in the morning and at night, while patients in the control group were treated with conventional basic therapy alone. Clinical symptom score and curative effect evaluation were collected at two time points (e.g. before treatment and after 7 days at end of treatment). All the data were calculated by using SPSS17.0 software. Results: The clinical symptom score between two groups was not statistically significant before treatment (P>0.05). After treatment, however, the sanguisorba oil group had a better clinical symptom score compared to control group (P<0.05). In addition, the main symptoms in the sanguisorba oil group including colpoxerosis, vaginal itching or burning, frequency, urgency or urodynia were largely alleviated after 10 days of treatment (P<0.05). No significant difference of clinical symptom score was found in control group after treatment (P>0.05). The clinical cure rate of the sanguisorba oil group and the control group were 7.1% and 0%, respectively, with significant difference (P<0.05). No adverse reaction was found during the treatment process in the two groups. Conclusions ：Taken together, external use of sanguisorba oil was effective in the treatment of TAM-related vaginitis and/or urinary irritation in breast cancer patients. With the advantage of convenience, safety and low price, sanguisorba oil treatment improves the compliance of breast cancer patients with TAM-related vaginitis, and should be promoted in clinical practice for oncologists.
Authors and Affiliations
Zhao Yuan-Hong, Han Su-Heng, Li Zheng, Luo Xiao-Yao, Long Xiu-Li, Li Shuai
Keywords
Related Articles
- EP ID EP45281
- DOI 10.12032/TMR201604027
- Views 269
- Downloads 0
The riddles of number nine in Chinese medicine processing method
The “nine cycles of steaming and shining”, “nine making”, “nine turns” and “nine cycles of calcining and quenching” methods that are recorded and used since ancient times are merely one aspect of the unique processing me...
Effects and safety of acupuncture for DFUs: a systematic review and meta-analysis
Objective:To systematically evaluate the effect and safety of acupuncture for the treatment of diabetic foot ulcers(DFUs).Methods:Six databases, including Pubmed, Web of Science, EMbase, the Cochrane Library, the Chinese...
“Banlangen (Radix isatidis) compound granules as a treatment for COVID-19”-the market value of Baiyunshan pharmaceutical soared by 10 billion RMB
On October 13, 2020, the fourth board meeting of the Guangdong-Macau Joint Research Centre for New Drug Discovery against respiratory pathogens and the Macau Symposium on Translation of Baiyunshan Banlangen and Coopera...
Quantitation of phytochemical constituents of Fumaria vaillantii L. with different extract methods
Objective: The genus fumaria includes more than 40 species in the world. The aim of this study was to quantify the phytochemical constituents of Fumaria vaillantii L. aerial parts and compare the different methods of ext...
The present treatment and mechanism progress of arsenic trioxide in hematological malignancies
This paper reviewed the development history of arsenic trioxide (ATO), and summarized its mechanisms and clinical application in the treatment of hematologic malignancies. ATO can induce tumor cell apoptosis, tumor cell...