A Prospective Study Comparing Oxaliplatin & 5-Fu with Gemcitabine & Cisplatin in Advanced Stage Carcinoma Gall Bladder
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 5
Abstract
Background: Overall incidence of Gallbladder (GB) malignancy is rare but it is the most common primary hepatobiliary carcinoma. Its incidence is highest in India and median survival is less than 6 months. Different chemotherapy regimens have been tried. These days Gemcitabine with cisplatin is the most preferred therapeutic approach but still less number of patients are achieving the 1 year survival. But studies on oxaliplatin and fluropyrimidine combination shows appreciative results in term of overall survival .These evidences led us for current prospective study to compare these two regimens in locally advanced carcinoma GB. Aim: The primary objective was to compare the overall survival while secondary objectives were to assess the response rate & toxicity. Method and Material: This single institution study included 50 cytopathologically proven advanced stage Carcinoma GB patients and randomized into ARM A (gemcitabine and cisplatin) and ARM B (oxaliplatin and 5FU). 4 Result: OS for arm A was 5± 0.504(95%CI, 4.012-5.988) months and for arm B was 5.5 ±.542 (95%CI , 44.37- 65.63)months. Most common side effects were nausea/vomiting and Anemia for arm A and arm B respectively. Conclusion: Oxaliplatin and 5-FU regimen can be considered as first line chemotherapy or second line chemotherapy in patients with advanced stage carcinoma GB. To confirm these results, study on larger number of patients population with advanced carcinoma GB needs to be undertake with randomization
Authors and Affiliations
M. Jain
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