A Randomized, Double-Blind Clinical Trial Comparing the Effects of 1% Ceramide, 10% Lanolin And 10% Urea Cream in Improving Skin Barrier Function of Children with Mild Atopic Dermatitis
Journal Title: International Journal of Science and Healthcare Research - Year 2018, Vol 3, Issue 4
Abstract
Objective: The aim of the study was to compare the effect of 1% ceramide, 10% lanolin and 10% urea cream in improving skin barrier function of mild childhood atopic dermatitis after 14 days of administration. Method: The study was conducted at the Pediatric Dermatology Clinic of the Dermatology and Venereology Department, Dr. Wahidin Sudirohusodo Hospital, and network hospitals in Makassar using a double-blind, randomized clinical trial. There were 16 children with mild atopic dermatitis included in this study, and they were divided into 4 treatment groups. Patients were randomly assigned to receive 1% ceramide cream, 10% lanolin cream, 10% urea cream, or vaseline (control group). Tewameter TM300 was being used to measure transepidermal water loss (TEWL) in the cubital fossa and popliteal fossa before and after 14 days of cream application. The data was analyzed using paired T-test. Result: Decrease in TEWL after 7 days in 1% ceramide, 10% lanolin, 10% urea and vaselin album were 13,71; 12,02; 11,45; and 9,43 consecutively. After 14 days, a more significant TEWL decrease in 1% ceramide, 10% lanolin, 10% urea and vaselin were 24,46; 21,63; 20,73; and 17,33 consecutively, with p<0,05. Conclusion: This study showed that 1% ceramide cream is more effective in reducing TEWL compared to 10% lanolin, 10% urea, and vaselin in children with atopic dermatitis after 14 days of application.
Authors and Affiliations
Farida Tabri
Keywords
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