A Retrospective Analytical Approach to Treatment Outcome of 40 Anemias
Journal Title: Medical Journal of Clinical Trials & Case Studies - Year 2020, Vol 4, Issue 1
Abstract
Objective: Anemia is clinical common event. There are many types of anemias, which included stem cell problems, vitamin deficiency, chronic diseases and drug antibody-induced immune hemolytic anemia. In this study, a retrospective purpose was investigated to assess the clinical efficacy of treatment and their outcome. Methods: 40 patients with different types of anemias were presented during 1989-2019. The therapeutical design among those patients with anemias was setted to the various regimen according to diseases diagnoses. Results and conclusion: 23 patients achieved cure or complete remission (CR), with the exception of refractory cancers and uremic anemia. Iron supplement was provided in 5 iron deficiency anemia. One megaloblastic anemia produced an excellent response following the supplement of vitamin B12 and folic acid. 2 aplastic anemia obtained complete remission (CR) with the integrated protocol of methyltestosterone,adenine, leucogen,and levamisol. Steroid hormone(e.g. prednisone) mixed traditional medicine were occasionally promising benefit in a nephrotic syndrome and renal insufficiency. Among 2 cases with drug-induced immune hemolytic anemia (DIIHA), laboratory studies one patient’s serum contained paracetamol-dependent antibody that in the presence of paracetamol, agglutinated in vitro with “O” red cells with or without complement. Drug antibody titer was 1:4 positive. The immune hemolysis was mediated via both immune complex and drug-adsorption, while another herba origanum vulgare- induced hemolysis secondary to drug adsorption only. In addition, as to anemia caused by malignant tumours, the molecular genetic regulation of retinoic acid in acute promyelocytic leukemia (APL) has been further illustrated (see figure in full text). Therefore, to strengthen the active prevention and/or early interceptive treatment of anemia is our care.
Authors and Affiliations
Zhu G*
Keywords
Related Articles
- EP ID EP756015
- DOI 10.23880/mjccs-16000254
- Views 34
- Downloads 0
DYRK1A (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A), a Master Regulatory Protein Involved in Down Syndrome Clinical Neurological Abnormalities and Associated Mental Retardation and a Promising Potential Drug Target for Therapeutics and Treatments
Over-expression of chromosome 21 genes, particularly in Down Syndrome Critical Region (DSCR), is the main cause of Down syndrome (DS) neuropathological features including mental retardation, cognitive impairments and ear...
Successful Surgical Intervention for a Congenital Perineomelia Associated with Atresia Ani and Rectovaginal Fistula in a Cow-Calf
Seven days old cow-calf was admitted to the Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt, with congenital malformations. Clinical examination revealed that the calf had...
Gorlin-Goltz Syndrome-Case Report and Review
The Gorlin-Goltz syndrome (GGS) or (the nevoid basal cell carcinoma syndrome—NBCCS) is a rare autosomal dominant and multiple organ syndrome. The common manifestations include multiple odontogenic keratocysts in the jaw...
Induction of Neutralizing Immunity against SARS-CoV-2 Omicron Variant by COVID-19 Vaccine Boosters
The Omicron variant (BA.1/B.1.1.529) is characterized by mutation of an unusually high number, with 26 to 32 changes (up to 36 mutations) in the spike (S) glycoprotein, the key epitopes (target) of neutralizing antibodie...
Down syndrome Provide Genetic Models and Key Roles of Human Chromosome 21 Gene Targets in the Elucidation of Molecular Pathways Associated to Cell Cycle Alterations, Leukaemia and Cancer for Development of Potential Drugs and Therapeutics
Trisomy 21 or Down syndrome, caused by the triplication of human chromosome 21, is the most frequent genetic disorder with hard impact on public health. The overdosage of genes on this chromosome determines transcription...