A Retrospective Non-Randomized Case Study Analysis of Mitomycin-C Efficacy in Patients Undergoing Combined Phacotrabeculectomy at a Tertiary Care Hospital in Salem, India
Journal Title: International Journal of Experimental Research and Review - Year 2023, Vol 36, Issue 7
Abstract
Glaucoma and cataracts, which are major contributors to worldwide blindness, frequently occur together, requiring phacotrabeculectomy as the primary therapeutic approach. This study conducted a retrospective analysis of cases to evaluate the efficacy of Mitomycin-C (0.2mg/ml for 3 min) in phacotrabeculectomy, which is a combination surgical treatment that involves trabeculectomy and phacoemulsification. The study was conducted over six months, from January 2022 to June 2022, in a tertiary care hospital in Salem. An analysis was conducted on the records of 60 patients who underwent phacotrabeculectomy and met the inclusion criteria. The study included 60 patients, with 28 (47%) being men and 32 (53%) being females; of these, 22 (37%) underwent surgery on their right eye, while 38 (63%) underwent surgery on their left. Most patients belonged to the age bracket of 51-65 years. The grading of cataracts identified many forms, such as Nuclear Sclerosis (NS-1: 3%, NS-1 and PSC: 10%, NS-2: 17%, NS-2 and PSC: 23%, NS-3: 7%, PSC: 13%). The most prevalent type, affecting the majority (27%) of the population, was Senile Immature Cataract (SIMC). The average preoperative intraocular pressure was 22.4 ± 1.52 mmHg, and after the surgery, the pressure reduced dramatically to 13.20 ± 1.42 mmHg. The difficulties associated with blebs are resolved on their own. After the operation, there was an improvement in visual acuity. The average values increased from 0.86 ± 0.15 before the surgery to 0.22 ± 0.26 on day 1, 0.20 ± 0.23 on day 7, 0.19 ± 0.23 on day 14, 0.18 ± 0.19 on day 30, and 0.18 ± 0.19 on day 45. A paired t-test demonstrated a statistically significant difference (p=0.02) in postoperative visual acuity between day 1 and day 45. The study's findings indicate that Mitomycin-C is efficacious in phacotrabeculectomy, resulting in decreased intraocular pressure and enhanced visual acuity, with no notable problems. The findings provide valuable insights into managing concurrent glaucoma and cataracts, presenting a viable strategy in tertiary care settings.
Authors and Affiliations
Arul Balasubramanian, Ezhilvendhan Kalaimamani, Rositta Siby Siby Kuttummelkattil, Kannan Murali, Karthick Kumar, Kothai Ramalingam
Keywords
Related Articles
- EP ID EP726756
- DOI 10.52756/ijerr.2023.v36.010
- Views 53
- Downloads 0
Experimental Investigation of Two-Pass Solar Dryer with V-Corrugated Absorber for Potato Slice Drying
Reducing the moisture level of food items can help prevent bacterial development and deterioration, extend shelf life, reduce packaging, and improve storage for convenient transportation. In this paper, a two-pass solar...
Improving Deposition Quality of Stellite Powder on Valve Seats by Optimized TIG Welding Parameters
The quality of the Stellite powder coated on these valve seats depends on the discharge profile and is crucial to the service length and quality of these seats, especially when called upon to work at their maximum capabi...
Technology adoption of digital banking and women consumers: An empirical investigation
Digital banking services have gained much attention in recent years due to their enormous advantages, like convenience, flexibility, and time-savings compared to traditional banking services. However, the low awareness,...
Variation in agronomic characters among traditional rice varieties of Cooch Behar, West Bengal: A Case Study
The expertise of agro-morphological variability within a crop and its dispersion across agro-ecological areas may be very useful in managing the crop's germplasm and developing improved methods. Crop failure is guarded a...
A Geo-Spatial analysis and assessment of groundwater potential zones by using remote sensing and GIS techniques-A micro level study of Bhagwanpur-I CD Block in Purba Medinipur District, West Bengal, India
The important resource of groundwater is a contributing significantly in total annual supply. However, over exploitation has depleted groundwater availability considerably and also led to land subsidence at some places....