A REVIEW OF ANTI-HYPERTENSION THERAPIES IN DIABETIC PATIENTS
Journal Title: Journal of Basic and Clinical Pharmacy - Year 2010, Vol 1, Issue 3
Abstract
The objective of this study was to review published articles on the issues surrounding tight blood pressure control in hypertensive diabetics.Relevant medical subject headings (MeSH) terms and keywords to review scientific literatures were developed. These MeSH terms were used to generate MEDLINE searches that focused on English-language, peer-reviewed scientific literature.In reviewing the exceptionally large body of research literature in anti-hypertension therapies in diabetic patients , the review focused on outcomes of importance to patients and effects of sufficient magnitude to warrant changes in medical practice (“patient oriented evidence that matters” [POEMs]).Patient-oriented outcomes include not only mortality but also other outcomes that affect patients’ lives and well-being. Studies of physiological end points (diseaseoriented evidence [DOEs]) were used to address questions where POEMs were not available.Treatment of hypertension in diabetic patients provides dramatic beneficial outcomes.Target diastolic BP of < 80 mmHg appears optimal; and systolic targets of 130mmHg or less are also reasonable. Studies that compare drug classes do not suggest obviously superior agents. However, it is reasonable to conclude that ACEIs, thiazide diuretics and angiotension II receptor blockers may be the preferred first-line agents for treatment of hypertension in diabetes. ACEIs, ARBs and low dose thiazide diuretics may be the first line treatments although other agents are usually necessary and goals may not be achieved even with three or four agents. Aggressive blood pressure control may be the most important factor in preventing adverse outcomes in hypertensive patients with diabetes.
Authors and Affiliations
Adibe Ogochukwu, UKWE VICTORIA
Keywords
Related Articles
- EP ID EP119501
- DOI -
- Views 127
- Downloads 0
Role of liquid membrane phenomenon in the anti-bacterial activity of Cefuroxime Sodium
The role of liquid membrane phenomenon has been studied in the anti bacterial activity of cephalosporins i.e. Cefuroxime sodium. In our earlier publication [1] it was reported that hydraulic permeability data obtained to...
AN OVERVIEW OF NUTRACEUTICALS: CURRENT SCENARIO
Using food products to promote health and cure disease is renowned.Currently, most of the drug molecules available in the formulations were ancientlyused in their crude form. Dr Stephen De Felice first coins the te...
FORMULATION AND EVALUATION OF ENTERIC COATED TABLETS OF PROTON PUMP INHIBITOR
The present study was an attempt to formulate and evaluate enteric coated tablets for esomeprazole magnesium trihydrate. Different core tablets were prepared and formulation (F-1) was selected for further enteric coating...
Preparation and In Vitro, In Vivo Evaluation of Clarithromycin Microcapsules
PURPOSE: To develop and validate a method to prepare clarithromycin (CLM) microcapsules to mask the bitter taste and provide effective treatment, and evaluate the quality of microcapsules in detail, especially the in vit...
Hepatoprotective effect of leaves of Peltophorum pterocarpum against paracetamol Induced acute liver damage in rats
The 70% ethanolic extract of Peltophorum pterocarpum leaves were investigated for its hepatoprotective effect against paracetamol induced acute liver damage on albino wister rats. Paracetamol (2gm/kg, po) significantly e...