A REVIEW OF ANTI-HYPERTENSION THERAPIES IN DIABETIC PATIENTS
Journal Title: Journal of Basic and Clinical Pharmacy - Year 2010, Vol 1, Issue 3
Abstract
The objective of this study was to review published articles on the issues surrounding tight blood pressure control in hypertensive diabetics.Relevant medical subject headings (MeSH) terms and keywords to review scientific literatures were developed. These MeSH terms were used to generate MEDLINE searches that focused on English-language, peer-reviewed scientific literature.In reviewing the exceptionally large body of research literature in anti-hypertension therapies in diabetic patients , the review focused on outcomes of importance to patients and effects of sufficient magnitude to warrant changes in medical practice (“patient oriented evidence that matters” [POEMs]).Patient-oriented outcomes include not only mortality but also other outcomes that affect patients’ lives and well-being. Studies of physiological end points (diseaseoriented evidence [DOEs]) were used to address questions where POEMs were not available.Treatment of hypertension in diabetic patients provides dramatic beneficial outcomes.Target diastolic BP of < 80 mmHg appears optimal; and systolic targets of 130mmHg or less are also reasonable. Studies that compare drug classes do not suggest obviously superior agents. However, it is reasonable to conclude that ACEIs, thiazide diuretics and angiotension II receptor blockers may be the preferred first-line agents for treatment of hypertension in diabetes. ACEIs, ARBs and low dose thiazide diuretics may be the first line treatments although other agents are usually necessary and goals may not be achieved even with three or four agents. Aggressive blood pressure control may be the most important factor in preventing adverse outcomes in hypertensive patients with diabetes.
Authors and Affiliations
Adibe Ogochukwu, UKWE VICTORIA
Keywords
Related Articles
- EP ID EP119501
- DOI -
- Views 128
- Downloads 0
Development of Chicken Egg Yolk Antibodies against Streptococcus mitis – Purification and Neutralizing Efficacy
Chicken Egg Yolk antibodies (IgY) were raised in 24 week old white leg horn chickens against Streptococcus mitis (MTCC 2696). The chickens received Booster injections of increasing concentrations of antigen to raise the...
ATTITUDE OF INTENDING COUPLE TOWARD COMPULSORY HIV SCREENING TEST: A MEANS TO CONTROL THE SPREAD OF HIV INFECTION
The objective of questionnaire based survey was to assess the attitude and acceptability toward compulsory HIV screening for the intending couple. A structure questionnaire was used to elicit responses from the couples....
Pyogenic Granuloma Successfully Treated With Electric Cautarization — Case Study
M.O is a 37 years old man complaining of a sudden small growth with continuous bleeding on his fi nger, erythematous, painless papule lesion (fi gure1). Th e lesion was very small in size, fi rm and shiny when fi rst not...
An Antioxidant potential of Hingot and Hadjod
The antioxidant activity of two plants - Hadjod i.e. Cissus quadrangularis (CQ) and Hingot i.e. Balanites aegyptiaca (BA) was determined by the thiocyanate method. The antioxidant activity of both the plants increa...
Novel Approaches in Formulation and Drug Delivery using Contact Lenses
The success of ocular delivery relies on the potential to enhance the drug bioavailability by controlled and extended release of drug on the eye surface. Several new approaches have been attempted to augment the competen...