A Review on Tablet Scoring: Background, History and Current Regulatory Considerations

Journal Title: Journal of Pharmaceutical Research International - Year 2017, Vol 20, Issue 5

Abstract

Tablet splitting or breaking of tablets into multiple strengths has been a common practice across the world. Splitting of tablet offers various advantages such as dose flexibility and ease of swallowing in different population including geriatric and pediatric patients (wide patient acceptance) and cost saving on medications (economic advantage) The tablet products that are meant to be split and approved by the Food and Drug Administration (FDA) will have a scored line indicating the split location to ensure patient can adjust the dose by splitting and such splitting information will be included in the patient package insert. Having a consistent scored reduces difficulty in dose related problems especially when using products made by different manufacturers such as Generic compared to Reference Listed Drugs (RLD). Physical characteristics such as shape, size and tablet score may affect tablet splitability. Currently, various regulatory bodies (FDA, USP, and EP) provide consistent and useful information to the pharmaceutical industry. In this review, authors have compiled information from currently available resources on tablet scoring.

Authors and Affiliations

Maitri R. Trivedi, Hardikkumar H. Patel, Rutesh H. Dave

Keywords

Related Articles

Influence of Process Parameters on Compressibility, Solubility and Release Characteristics of Melt Sonocrystallized Fenofibrate

Aims: The aim of the present study was to investigate the suitability of the melt sonocrystallization (MSC) technique to modify the processability properties along with solubility and drug release of anti-hyperlipidemic...

Investigate the Effect of Fatty Acids on Rheological Properties and In vitro Permeability of Escitalopram Oxalate from Hydroxypropyl Cellulose Gel Formulations

The present studies evaluate rheological properties and in-vitro permeability properties of Escitalopram Oxalate (ECO) containing hydroxypropyl cellulose (Klucel HF, HPC) gels prepared with different carbon chain length...

Evaluation of Antioxidant and Antiacne Activity of Psorospermum febrifugum (Spach) and Psorospermum corymbiferum (Hochr.)

Aim: This study investigated the anti-acne activity, lipase inhibitory effects and antioxidant property of Psorospermum febrifugum and Psorospermum corymbiferum of the family Hypericaceae. Study Design: Antimicrobial as...

Anti-Mycobacterium Metabolite from Marine Sponge Iricinia fusca

Chemical investigation of the marine sponge Ircinia fusca leads to isolation of a new pyrrole derivative (1) and two known compounds namely, 3 methyl decanoic acid (2) and Benzenedicarboxylic acid (3). The structures of...

Pre-clinical Evaluation of the Hypotensive and Anti Atherogenic Activity of Hydroethanolic Extract of Eribroma oblongum (Malvaceae) Stem Bark on Wistar Rats Models

Aims: The stem bark of Eribroma oblongum (Malvaceae) is used in traditional Cameroonian medicine to treat various metabolic illnesses including the management of hypertension without scientific evidence to how relief is...

Download PDF file
  • EP ID EP313157
  • DOI 10.9734/JPRI/2017/39027
  • Views 106
  • Downloads 0

How To Cite

Maitri R. Trivedi, Hardikkumar H. Patel, Rutesh H. Dave (2017). A Review on Tablet Scoring: Background, History and Current Regulatory Considerations. Journal of Pharmaceutical Research International, 20(5), 1-7. https://www.europub.co.uk/articles/-A-313157