A Review on The Protective Effects of Metformin in Sepsis-Induced Organ Failure
Journal Title: Cell Journal(Yakhteh) - Year 2020, Vol 21, Issue 4
Abstract
Despite advances in sepsis management, it remains a major intensive-care-unit (ICU) concern. From new prospective, positive effects of metformin, such as anti-oxidant and anti-inflammatory properties are considered potentially beneficial properties for management of septic patients. This article reviewed the potential ameliorative effects of metformin in sepsis-induced organ failure. Information were retrieved from PubMed, Scopus, Embase, and Google Scholar. Multi-organ damage, oxidative stress, inflammatory cytokine stimulation, and altered circulation are hallmarks of sepsis. Metformin exerts its effect via adenosine monophosphate-activated protein kinase (AMPK) activation. It improves sepsis-induced organ failure by inhibiting the production of reactive oxygen species (ROS) and pro-inflammatory cytokines, preventing the activation of transcription factors related to inflammation, decreasing neutrophil accumulation/infiltration, and also maintaining mitochondrial membrane potential. Studies reported the safety of metformin therapeutic doses, with no evidence of lactic acidosis, in septic patients.
Authors and Affiliations
Fatima Ismail Hassan, Tina Didari, Fazlullah Khan, Kamal Niaz, Mojtaba Mojtahedzadeh, Mohammad Abdollahi
Keywords
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- EP ID EP624534
- DOI 10.22074/cellj.2020.6286
- Views 172
- Downloads 0
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