Abstract

Among the various drug delivery systems, transdermal drug delivery plays an important role. Iontophoresis, electrophoresis, sonophoresis, chemical permeation enhancers, microneedles, and vesicular constructs are different methods which supports transdermal drug delivery. Vesicular constructs includes liposomes, niosomes, virosomes, ethosomes and transfersomes. The transfersomal drug delivery system was much more efficient among all these types. Transfersomes can pass through narrow constriction of 5 to 10 times less than their own diameter, without any measurable drug loss. The transfersomal drug delivery system can be evaluated by in vitro for vesicle shape and size, entrapment efficiency, degree of deformability and number of vesicles. The deformability characteristic of transfersomes gives better drug permeability. They can act as a carrier for both low and high molecular weight drugs like insulin analgesics, anaesthetics, sex hormones, corticosteroids, etc. Keywords: Transfersomes, skin permeability, Thin film hydration technique

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