A Study of Acute Kidney Injury in Patients with Snakebite Envenomation
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 4
Abstract
Background and Objectives: Since long Snakebite-related acute kidney injury (AKI) is a common community-acquired AKI in tropical countries leading to death and disability. The aims of this study were to (1) determine the occurrence of snakebite-related AKI, (2) assess factors at presentation that are associated with snakebite-related AKI, and (3) determine the outcomes of patients with snakebiterelated AKI. Methods: We conducted a prospective observational study of patients with snake envenomation at our tertiary hospital during the calender year of 2016. Patient data including baseline characteristics, clinical and laboratory findings, hospital management, and outcomes were recorded in a case report form. A stepwise multivariate logistic regression analysis using a backward selection method determined independent factors significantly associated with AKI. Results: AKI was observed in 140 patients (54.3%), the majority of whom were AKI stage III (110 patients, 78.6%). AKI occurred at presentation and developed during hospitalization in 88 (62.9%) and 52 patients (37.1%), respectively. Twenty-seven patients died (19.3%), and 69 patients (49.3%) required dialysis. On multivariate logistic regression analysis, (1) snakebites from the Viperidae family (odds ratio [OR]: 9.65, 95% confidence interval [CI]: 2.42–38.44; p = 0.001), (2) WBC >10 × 103 cells/μL (OR: 3.55, 95% CI: 1.35–9.34; p = 0.010), (3) overt disseminated intravascular coagulation (OR: 2.23, 95% CI: 1.02–4.89; p = 0.045), (4) serum creatine kinase >500 IU/L (OR: 4.06, 95% CI: 1.71–9.63; p = 0.001), (5) serum sodium <135 mmol/L (OR: 4.37, 95% CI: 2.04– 9.38; p < 0.001), (6) presence of microscopic hematuria (OR: 3.60, 95% CI: 1.45–8.91; p = 0.006) Conclusions: If we dentify factors associated with snakebite-related AKI might help clinicians to be aware of snakebite patients who are at risk of AKI, particularly patients who demonstrate renal tubular dysfunction after Viperidae bites.
Authors and Affiliations
Pranay Gandhi
Keywords
Related Articles
- EP ID EP281404
- DOI -
- Views 97
- Downloads 0
Electrophysiological Changes in Uncontrolled Type-2 Diabetic People with Peripheral Neuropathy
Introduction: Diabetes mellitus the incidence of which is very high in our nation and presenting as a serious health problem. Some of its serious complications are retinopathy, neuropathy, nephropathy and vascular proble...
Histopathological Diagnosis of Ovarian Fibroma: A Rare Case Report
In the WHO histopathological classification of tumors of the ovary, fibroma is classified under the sex cord - stromal tumors. Ovarian fibroma is almost always benign in. They are rare in women under 20 years of age, occ...
Collision Tumor of Thyroid: A Rare Case Report
Abstract
Rural-Urban and Gender Differences in Risk Factors for Acute Coronary Syndrome
An emic approach in the identification of risk factors for Acute Coronary Syndrome (ACS) is important as their relative importance may vary between genders and across different backgrounds. The current study was undertak...
Hypofractionated Radiation with concurrent Cisplatin plus Erlotinib in locally advanced squamous cell carcinomas of head and neck: A Feasibility Phase II Study of a Single Institute
Aim: To study the feasibility hypofractionated radiation along with standard concurrent Cisplatin plus Erlotinib in Locally advanced squamous cell carcinoma of head and neck (LASCCHN). Method and Materials: A prospective...