A Study of Adiponectin in Children with Diabetes Mellitus
Journal Title: Sultan Qaboos University Medical Journal - Year 2013, Vol 13, Issue 2
Abstract
Objectives: Adiponectin is a hormone produced by adipose tissue. It is secreted exclusively by adipocytes and appears to play a role in the pathophysiology of obesity, diabetes mellitus (DM), and its comorbidities. Te aim of this study was to assess adiponectin levels in diabetic children with type 1 DM (T1DM) and type 2 DM (T2DM), and to detect its prognostic role in them. Methods: Tis study was undertaken from April to July 2011 at Minia University Children’s Hospital, Egypt, and included 314 children aged 2–18 years divided into two patient groups. Group I consisted of 164 pre-diagnosed diabetic patients, further subdivided into Group Ia which included 142 patients with T1DM and Group Ib, 22 patients with T2DM; Group 2 included 150 apparently healthy children as a controls; they were age- and sex-matched to the diseased group. Patients were subjected to a thorough history taking, clinical examination, and laboratory investigations including assessment of HbA1c percentages, fasting C-peptide levels, lipid profles and fasting serum adiponectin levels. Results: Adiponectin levels did not differ signifcantly between patients with T1DM and T2DM, but it was signifcantly higher in diabetic patients than in the controls. In T1DM, adiponectin had positive signifcant correlations with the duration of the disease and waist circumference, while in T2DM, it had a positive signifcant correlation with the dose of insulin given and negative signifcant associations with diastolic blood pressure, cholesterol, and C-peptide levels. Conclusion: Te results of the study suggest that adiponectin can play a protective role against the metabolic complications of DM.
Authors and Affiliations
Basma A. Ali| Paediatric and Biochemistry Departments, Minia University, Minia, Egypt, Doaa M. Mahrous| Paediatric and Biochemistry Departments, Minia University, Minia, Egypt, Ahlam M. Abdallah| Biochemistry Departments, Minia University, Minia, Egypt, Mina Fikri| Paediatric and Biochemistry Departments, Minia University, Minia, Egypt
Keywords
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