A Study of Cardiac Parameters using Impedance Plethysmography (IPG) in Healthy Volunteers
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2012, Vol 2, Issue 11
Abstract
Impedance plethysmography is non – invasive technique to measure blood flow in any part of the body like heart (Impedance Cardiography), arteries or veins. As only heart rate and blood pressure is not sufficient to access a person‟s hemodynamic status, cardiac output and other cardiac parameters measured by this simple technique will help further to access heart‟s functional status with avoidance of all complications associated with previous catheter related invasive techniques. Main aim of the study was to measure cardiac parameters noninvasively in healthy volunteers of all age groups of both sex using impedance cardiography and then compare them between different age groups. Study was done in 5 age groups (16 – 25 yrs, 26 – 35 yrs, 36 – 45 yrs, 46 – 55 yrs and > 55 yrs) and in total 400 subjects. Each group was of 80 healthy volunteers of either sex. It was carried out on Nivomon Series computerized software in Bhavnagar region. Cardiac parameters measured were SV – Stroke Volume, SI - Stroke Volume Index, CO – Cardiac Output, CI – Cardiac Index, LVET – Left Ventricular Ejection Time, SVR – Systemic Vascular Resistance and SVRI - Systemic Vascular Resistance Index. Normative baseline laboratory data obtained from 400 healthy volunteers were as: SV - 65.15 ± 13.18 ml / beat, SI - 38.16 ± 7.64 ml / beat / m², CO - 4.94 ± 1.09 lit. / min, CI - 2.91 ± 0.51 lit. / min / m², LVET - 357.35 ± 46.32 msecs, SVR - 1500.95 ± 305.45 dyne•sec / cm5 and SVRI - 2507.75 ± 441.63 dyne•sec / cm5 / m². These values were found to be consistent with normal reference range. So now these baseline normative data will be helpful in many future research studies related to heart function in Bhavnagar region for this novel instrument. Significant differences were found for all parameters between different age groups. LVET and SVR were found on higher side in later ages due to atherosclerosis and other age related changes. Positive correlation was found between BSA and SV, CO. Negative was the case for BSA and SVR. In case of gender difference in last age group, Zo was found to be extremely higher in females due to higher fat proportion. Also SV was significantly lower and SVR was higher in females but no difference was there for CO and LVET. Overall, cardiac parameters were measured with this impedance technique accurately. Although there were some limitations, this technique was found to be simple, cheap and effective. If this technique is further validated and established, than it can be used widely for many physiological and pharmacological studies on human heart. Further, it can be used in ICU, in clinical set up for many heart disease patients, and also in CCU or in emergency trauma centres for other critically ill patients.
Authors and Affiliations
C. V. Parmar , D. L. Prajapati , V. V. Chavda , P. A. Gokhale , H. B. Mehta , C. J. Shah
Keywords
Related Articles
- EP ID EP141308
- DOI -
- Views 117
- Downloads 0
Analgesic and Anti-Inflammatory Activities of Dichrostachys glomerata (Forssk.) Hutch. Fruits Methanolic Extract in Rats
The present study has been undertaken to assess the analgesic and the anti-inflammatory properties of methanolic extract Dichrostachys glomerata fruit. Pain was induced in mice by the intraperitoneal administration of 1...
Identification of Gingerols in Ginger (Zingiber officinale Roscoe) by High Performance Liquid Chromatography-Tandem Mass Spectrometry and Pharmacologic Studies of its Aqueous Extract on the Rabbit Isolated Duodenum Contractility
Ginger (Zingiber officinale Roscoe, Zingiberaceae) is a plant used in traditional medicine in Côte d’Ivoire, notably for asthma attacks. In various medical traditions, rhizome of the plant is indicated as a cough-drop, a...
Gongronema Latifolium: A Phytochemical, Nutritional and Pharmacological Review
[i]Gongronema[/i] [i]latifolium[/i] (Amaranth globe) is popularly known for its nutritional and medicinal values. The health benefits of different parts of this plant cannot be over emphasized especially in traditiona...
Hepatotoxic and Nephrotoxic Effects of Kerosene on Female Wistar Rats: a Comparison of Two Routes of Exposure
The aim of this study is to determine the hepato & nephrotoxic effects of kerosene in Wistar rats and compare the effects of oral and dermal routes of administration. Hepatic & renal indices such as alanine &...
A Microscopic Study of the Aortic Branches Structure in the Adult Male Dog
The aim of the present study was to determine the structural changes between elastic and muscular artery in branches (ciliac artery, mesenteric artery, renal artery) of aorta. Five normal adult male dogs were studied and...