A STUDY OF HISTOPATHOLOGICAL AND BIOCHEMICAL CHANGES OF LIVER IN TUBERCULOSIS
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 38
Abstract
BACKGROUND Infection with mycobacterium tuberculosis is most often found in well-oxygenated areas of the body such as the apices of the lung and renal cortex, it does affect liver in many ways. This kind of infection in the liver is usually secondary from TB of the lung or other organ. The aim of this study is to assess the liver function test abnormalities and histopathological changes on liver biopsy in tuberculosis and to correlate with biochemical and histopathological changes in tuberculosis patients. MATERIALS AND METHODS This cross-sectional observational study was carried out on 50 cases of tuberculosis patients admitted in medical wards at KIMS Hospital, Hubli. Out of 50 study participants, 40 were suffering from pulmonary and remaining 10 from disseminated tuberculosis. The need for liver biopsy was clinically assessed by the evaluating hepatologist following a complete physical examination and appropriate radiological imaging. Vitamin K 5 mg/day was given IM for three consecutive days prior to liver biopsy ruling out all contraindications and coagulation or bleeding disorders. RESULTS In this study, male-to-female ratio was 3.5:1 with peak incidence among 20-40 years of age. Chest x-ray revealed nonhomogenous fibrocaseous lesions in 86% followed by cavitatory lesions in 52% of cases. Hepatic granuloma was 12% all being seen in disseminated tuberculosis. Nonspecific changes were seen in 88% of cases. Most common being fatty infiltration (64%) and lymphocytic infiltration (68%). CONCLUSION This study concluded that the incident of hepatic granuloma was seen in disseminated tuberculosis. Diagnosis of hepatobiliary tuberculosis should be considered in any patient with hepatomegaly, especially if accompanied by weight loss and in suspicious cases, a liver biopsy should be performed without delay, since this condition responds well to early antituberculous therapy.
Authors and Affiliations
Kalinga Bommankatte Eranaik, Santosh Vastrad, Basangouda Sangangouda Patil
Keywords
Related Articles
- EP ID EP219118
- DOI 10.18410/jebmh/2017/445
- Views 94
- Downloads 0
STUDY TOPIC- ROLE OF USG AND CT IN IMAGING OF THYROID LESIONS
BACKGROUND Thyroid lesions are the most common abnormality in the endocrine system. The importance of imaging is that cancers of the thyroid must be differentiated from the much more frequent benign adenomas and multinod...
A STUDY ON OUTBREAK OF CARBAPENEM PLUS COLISTIN-RESISTANT KLEBSIELLA PNEUMONIAE SEPSIS IN NEWBORNS IN A NURSERY OF A TERTIARY CARE HOSPITAL
BACKGROUND A retrospective study was performed in a nursery of a tertiary care hospital in Jamshedpur, India, between March 2016 and July 2016. There was an outbreak of carbapenem+colistin resistant Klebsiella during tha...
RELIABILITY OF NASION-BREGMA LENGTH MEASUREMENT IN IDENTIFICATION OF SEX OF SKULL
Determination of sex from the skeletal remains is of medico legal importance for establishing the identity of an individual. The determination of deceased sex is first step in skeletal analysis since estimation of age at...
EXTENT OF IMPROVEMENT IN BINOCULARITY AND STEREOPSIS IN CONSTANT CONCOMITANT HORIZONTAL STRABISMUS AFTER SURGICAL MANAGEMENT AND ITS ASSOCIATION WITH THE POSTOPERATIVE OCULAR ALIGNMENT
BACKGROUND The gradual decrease in binocularity and stereopsis in patients with concomitant strabismus decreases the depth perception of the patients and adversely affects the reading speed and the motor dexterity skills...
ANESTHETIC MANAGEMENT OF A PATIENT WITH HISTORY OF MALIGNANT HYPERTHERMIA
Malignant hyperthermia (MH) is a very rare life threatening condition. It has an incidence of 1:4,500 to 1:60,000 patients undergoing general anaesthesia. Disorder occurs worldwide and affects all racial groups. Clinical...