A Study of Neurodevelopmental Outcome in Hyperbilirubinaemic Neonates Admitted in NICU
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 6, Issue 1
Abstract
ABSTRACT Introduction: Hyperbilirubinaemia may be toxic to the developing central nervous system and may cause neurological impairment. The developing brain of premature babies is extremely vulnerable to injury. With increased level of bilirubin, the risk for neurodevelopmental deficit increases with decreasing gestational age and birth weight resulting in relatively high risk of cerebral palsy, developmental delay, hearing and vision impairment and subnormal academic achievement. Aim: This study was conducted to identify factors and pattern of abnormal neurodevelopment at three and 12 months in babies having birth weight >1.5 Kg and gestational age >34 weeks with neonatal hyperbilirubinaemia. Materials and Methods: This prospective study was conducted at Sardar Patel Medical College, Bikaner (Rajasthan), India, from 2014 to 2015. Hyperbilirubinaemia in newborns were examined at three month and 12 month age and their neurodevelopmental assessment done by DASI method. All the collected data was tabulated and stastically analysed by using SPSS software. Results: Out of 96, 67 (69.79%) of hyperbilirubinaemic neonates were males and 29 (30.21%) were females. The prevalence of neurodevelopmental abnormalities (DQ≤70) was 10.42% at three months where as it was 6.25% at 12 months follow-up. Early onset of jaundice (≤1 day), serum bilirubin level >25 mg/dL, duration of hospital stay >3 days and requirement of exchange transfusion was significantly associated with adverse neurodevelopmental outcomes (DQ≤70) at three and 12 months of age. Conclusion: This study found a high prevalence of adverse neurodevelopmental outcome in neonates with hyperbilirubinaemia. Early detection of neurodevelopmental abnormalities and initiation of early intervention measures to reduce the prevalence of neurodevelopmental abnormalities in hyperbilirubinaemic neonates.
Authors and Affiliations
Monika Sharma
Keywords
Related Articles
- EP ID EP521086
- DOI 10.7860/IJNMR/2018/23725.2225
- Views 91
- Downloads 0
Krishna Institute of Medical Sciences University, Karad, Maharashtra, India.
Secondary Acute Angle Closure Glaucoma (AACG) is a known side effect of Topiramate (TPM). Here, we present a case report of a 47-year-old male who was started on TPM 25 mg/day for migraine. He presented to the ophthalmol...
Perforated Jejunal Diverticulitis: An Uncommon Cause of Abdominal Pain
ABSTRACT Diverticular disease of the jejunum is a rare entity. Most patients with small bowel diverticula are asymptomatic. Patients who develop symptoms generally report symptoms that reflect associated complications. T...
Ankylosing Spondylitis Causing Obstructive Lung Disease and Tricuspid Insufficiency: A Case Report
ABSTRACT Ankylosing Spondylitis (AS) is a chronic progressive inflammatory spondyloarthropathy typically involving the axial skeleton, especially the sacroiliac joints and spine. Genetic predisposition in AS leads to its...
The Potential Curative and Prophylactic Effects of Grape Seed Extract on Aspirin Induced Gastric Ulcer in Adult Male Albino Rats
ABSTRACT Introduction: Aspirin {Acetyl Salicylic Acid (ASA)} is a potent Nonsteroidal Anti-Inflammatory Drug (NSAID). Gastric ulcer associated with the use of aspirin is a major problem. Grape Seed Extract (GSE), has bee...
Acute Liver Injury, Rhabdomyolysis and Acute Renal Failure in a Toddler due to Multiple Stings by Vespa affinis
ABSTRACT Vespa affinis stings are known to produce local as well as systemic toxic manifestations including haemolysis, rhabdomyolysis, renal injury, hepatic toxicity and encephalopathy. However, very few pediatric cases...